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dc.contributor.authorSmart, NA
dc.contributor.authorKing, N::0000-0001-6989-5760
dc.contributor.authorLambert, JD
dc.contributor.authorPearson, MJ
dc.contributor.authorCampbell, JL
dc.contributor.authorRisom, SS
dc.contributor.authorTaylor, RS

<jats:sec><jats:title>Objective</jats:title><jats:p>The aim of this study was to undertake a contemporary review of the impact of exercise-based cardiac rehabilitation (CR) targeted at patients with atrial fibrillation (AF).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We conducted searches of PubMED, EMBASE and the Cochrane Library of Controlled Trials (up until 30 November 2017) using key terms related to exercise-based CR and AF. Randomised and non-randomised controlled trials were included if they compared the effects of an exercise-based CR intervention to a no exercise or usual care control group. Meta-analyses of outcomes were conducted where appropriate.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The nine randomised trials included 959 (483 exercise-based CR vs 476 controls) patients with various types of AF. Compared with control, pooled analysis showed no difference in all-cause mortality (risk ratio (RR) 1.08, 95% CI 0.77 to 1.53, p=0.64) following exercise-based CR. However, there were improvements in health-related quality of life (mean SF-36 mental component score (MCS): 4.00, 95% CI 0.26 to 7.74; p=0.04 and mean SF-36 physical component score: 1.82, 95% CI 0.06 to 3.59; p=0.04) and exercise capacity (mean peak VO<jats:sub>2</jats:sub>: 1.59 ml/kg/min, 95% CI 0.11 to 3.08; p=0.04; mean 6 min walk test: 46.9 m, 95% CI 26.4 to 67.4; p&lt;0.001) with exercise-based CR. Improvements were also seen in AF symptom burden and markers of cardiac function.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Exercise capacity, cardiac function, symptom burden and health-related quality of life were improved with exercise-based CR in the short term (up to 6 months) targeted at patients with AF. However, high-quality multicentre randomised trials are needed to clarify the impact of exercise-based CR on key patient and health system outcomes (including health-related quality of life, mortality, hospitalisation and costs) and how these effects may vary across AF subtypes.</jats:p></jats:sec>

dc.publisherBMJ Publishing Group
dc.subjectatrial fibrillation
dc.subjectexercise training
dc.subjecthealth-related quality of life
dc.titleExercise-based cardiac rehabilitation improves exercise capacity and health-related quality of life in people with atrial fibrillation: a systematic review and meta-analysis of randomised and non-randomised trials.
dc.typeJournal Article
dc.typeResearch Support, Non-U.S. Gov't
plymouth.journalOpen Heart
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Biomedical Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.rights.embargoperiodNot known
rioxxterms.typeJournal Article/Review

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