Show simple item record

dc.contributor.authorPearson, MJ
dc.contributor.authorKing, N
dc.contributor.authorSmart, NA
dc.date.accessioned2018-08-03T09:04:35Z
dc.date.issued2018-07
dc.identifier.issn2053-3624
dc.identifier.issn2053-3624
dc.identifier.otherUNSP e000819
dc.identifier.urihttp://hdl.handle.net/10026.1/11974
dc.description.abstract

<jats:sec><jats:title>Background</jats:title><jats:p>Biomarkers are important in the diagnosis, risk stratification and management of patients with heart failure (HF). The established biomarkers of myocardial stretch, brain natriuretic peptide (BNP) and amino (N) portion of BNP (NT-proBNP) have been extensively studied, and early analyses have demonstrated response to exercise training. Several other biomarkers have been identified over the last decade and may provide valuable and complementary information which may guide treatment strategies, including exercise therapy.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A systematic search of PubMed, EMBASE and Cochrane Trials Register to 31 October 2017 was conducted for exercise-based rehabilitation trials in HF. Randomised and controlled trials that reported biomarkers, BNP, NT-proBNP, soluble ST2, galectin-3, mid-regional atrial natriuretic peptide, mid-regional adrenomedullin and copeptin, were included.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Forty-three studies were included in the systematic review, with 27 studies suitable for meta-analyses. Data pooling was only possible for NT-proBNP and BNP. Meta-analyses of conventional training studies demonstrated a statistically significant improvement in NT-proBNP (pmol/L); mean difference (MD) −32.80 (95% CI −56.19 to −9.42), p=0.006 and in BNP (pmol/L); MD −17.17 (95% CI −29.56 to −4.78), p=0.007. Pooled data of non-conventional training failed to demonstrate any statistically significant improvements.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Pooled data indicated a favourable effect of conventional exercise therapy on the established biomarkers, NT-proBNP and BNP; however, this was in contrast to a number of studies that could not be pooled. Limited evidence exists as to the effect of exercise training on emerging biomarkers.</jats:p></jats:sec>

dc.format.extente000819-e000819
dc.format.mediumElectronic-eCollection
dc.languageen
dc.language.isoen
dc.publisherBMJ
dc.subjectB-type natriuretic peptide
dc.subjectbiomarkers
dc.subjectbrain natriuretic peptide
dc.subjectexercise
dc.subjectheart failure
dc.titleEffect of exercise therapy on established and emerging circulating biomarkers in patients with heart failure: a systematic review and meta-analysis
dc.typejournal-article
dc.typeReview
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/30018779
plymouth.issue2
plymouth.volume5
plymouth.publisher-urlhttp://dx.doi.org/10.1136/openhrt-2018-000819
plymouth.publication-statusPublished
plymouth.journalOpen Heart
dc.identifier.doi10.1136/openhrt-2018-000819
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Biomedical Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeEngland
dcterms.dateAccepted2018-05-24
dc.rights.embargodate2018-8-11
dc.identifier.eissn2053-3624
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1136/openhrt-2018-000819
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-07
rioxxterms.typeJournal Article/Review


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record


All items in PEARL are protected by copyright law.
Author manuscripts deposited to comply with open access mandates are made available in accordance with publisher policies. Please cite only the published version using the details provided on the item record or document. In the absence of an open licence (e.g. Creative Commons), permissions for further reuse of content should be sought from the publisher or author.
Theme by 
Atmire NV