The effect of dietary nitrate supplementation on the spatial heterogeneity of quadriceps deoxygenation during heavy-intensity cycling.
dc.contributor.author | Breese, Brynmor | |
dc.contributor.author | Poole, DC | |
dc.contributor.author | Okushima, D | |
dc.contributor.author | Bailey, SJ | |
dc.contributor.author | Jones, AM | |
dc.contributor.author | Kondo, N | |
dc.contributor.author | Amano, T | |
dc.contributor.author | Koga, S | |
dc.date.accessioned | 2018-05-01T12:15:15Z | |
dc.date.issued | 2017-07-25 | |
dc.identifier.issn | 2051-817X | |
dc.identifier.issn | 2051-817X | |
dc.identifier.uri | http://hdl.handle.net/10026.1/11382 | |
dc.description.abstract |
This study investigated the influence of dietary inorganic nitrate (NO3(-)) supplementation on pulmonary O2 uptake (V˙O2) and muscle deoxyhemoglobin/myoglobin (i.e. deoxy [Hb + Mb]) kinetics during submaximal cycling exercise. In a randomized, placebo-controlled, cross-over study, eight healthy and physically active male subjects completed two step cycle tests at a work rate equivalent to 50% of the difference between the gas exchange threshold and peak V˙O2 over separate 4-day supplementation periods with NO3(-)-rich (BR; providing 8.4 mmol NO3(-)∙day(-1)) and NO3(-)-depleted (placebo; PLA) beetroot juice. Pulmonary V˙O2 was measured breath-by-breath and time-resolved near-infrared spectroscopy was utilized to quantify absolute deoxy [Hb + Mb] and total [Hb + Mb] within the rectus femoris, vastus lateralis, and vastus medialis There were no significant differences (P > 0.05) in the primary deoxy [Hb + Mb] mean response time or amplitude between the PLA and BR trials at each muscle site. BR significantly increased the mean (three-site) end-exercise deoxy [Hb + Mb] (PLA: 91 ± 9 vs. BR: 95 ± 12 μmol/L, P < 0.05), with a tendency to increase the mean (three-site) area under the curve for total [Hb + Mb] responses (PLA: 3650 ± 1188 vs. BR: 4467 ± 1315 μmol/L sec(-1), P = 0.08). The V˙O2 slow component reduction after BR supplementation (PLA: 0.27 ± 0.07 vs. BR: 0.23 ± 0.08 L min(-1), P = 0.07) correlated inversely with the mean increases in deoxy [Hb + Mb] and total [Hb + Mb] across the three muscle regions (r(2) = 0.62 and 0.66, P < 0.05). Dietary NO3(-) supplementation increased O2 diffusive conductance across locomotor muscles in association with improved V˙O2 dynamics during heavy-intensity cycling transitions. | |
dc.format.extent | e13340-e13340 | |
dc.format.medium | ||
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.subject | Heterogeneity | |
dc.subject | nitrate supplementation | |
dc.subject | oxygen delivery | |
dc.subject | oxygen utilization | |
dc.subject | time resolved near‐infrared spectroscopy | |
dc.title | The effect of dietary nitrate supplementation on the spatial heterogeneity of quadriceps deoxygenation during heavy-intensity cycling. | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Randomized Controlled Trial | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/28743821 | |
plymouth.issue | 14 | |
plymouth.volume | 5 | |
plymouth.publication-status | Published | |
plymouth.journal | Physiol Rep | |
dc.identifier.doi | 10.14814/phy2.13340 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/School of Biomedical Sciences | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2017-05-23 | |
dc.rights.embargodate | 2018-6-15 | |
dc.identifier.eissn | 2051-817X | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.14814/phy2.13340 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2017-07-25 | |
rioxxterms.type | Journal Article/Review |