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dc.contributor.authorBreese, BCen
dc.contributor.authorPoole, DCen
dc.contributor.authorOkushima, Den
dc.contributor.authorBailey, SJen
dc.contributor.authorJones, AMen
dc.contributor.authorKondo, Nen
dc.contributor.authorAmano, Ten
dc.contributor.authorKoga, Sen
dc.date.accessioned2018-05-01T12:15:15Z
dc.date.issued2017-07-25en
dc.identifier.urihttp://hdl.handle.net/10026.1/11382
dc.description.abstract

This study investigated the influence of dietary inorganic nitrate (NO3(-)) supplementation on pulmonary O2 uptake (V˙O2) and muscle deoxyhemoglobin/myoglobin (i.e. deoxy [Hb + Mb]) kinetics during submaximal cycling exercise. In a randomized, placebo-controlled, cross-over study, eight healthy and physically active male subjects completed two step cycle tests at a work rate equivalent to 50% of the difference between the gas exchange threshold and peak V˙O2 over separate 4-day supplementation periods with NO3(-)-rich (BR; providing 8.4 mmol NO3(-)∙day(-1)) and NO3(-)-depleted (placebo; PLA) beetroot juice. Pulmonary V˙O2 was measured breath-by-breath and time-resolved near-infrared spectroscopy was utilized to quantify absolute deoxy [Hb + Mb] and total [Hb + Mb] within the rectus femoris, vastus lateralis, and vastus medialis There were no significant differences (P > 0.05) in the primary deoxy [Hb + Mb] mean response time or amplitude between the PLA and BR trials at each muscle site. BR significantly increased the mean (three-site) end-exercise deoxy [Hb + Mb] (PLA: 91 ± 9 vs. BR: 95 ± 12 μmol/L, P < 0.05), with a tendency to increase the mean (three-site) area under the curve for total [Hb + Mb] responses (PLA: 3650 ± 1188 vs. BR: 4467 ± 1315 μmol/L sec(-1), P = 0.08). The V˙O2 slow component reduction after BR supplementation (PLA: 0.27 ± 0.07 vs. BR: 0.23 ± 0.08 L min(-1), P = 0.07) correlated inversely with the mean increases in deoxy [Hb + Mb] and total [Hb + Mb] across the three muscle regions (r(2) = 0.62 and 0.66, P < 0.05). Dietary NO3(-) supplementation increased O2 diffusive conductance across locomotor muscles in association with improved V˙O2 dynamics during heavy-intensity cycling transitions.

en
dc.language.isoenen
dc.subjectHeterogeneityen
dc.subjectnitrate supplementationen
dc.subjectoxygen deliveryen
dc.subjectoxygen utilizationen
dc.subjecttime resolved near‐infrared spectroscopyen
dc.titleThe effect of dietary nitrate supplementation on the spatial heterogeneity of quadriceps deoxygenation during heavy-intensity cycling.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/28743821en
plymouth.issue14en
plymouth.volume5en
plymouth.publication-statusPublisheden
plymouth.journalPhysiol Repen
dc.identifier.doi10.14814/phy2.13340en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Biomedical Research Group
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Biomedical Research Group/RC Reporting Group BRG
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/School of Biomedical Sciences
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
dcterms.dateAccepted2017-05-23en
dc.rights.embargodate2018-06-15en
dc.identifier.eissn2051-817Xen
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.14814/phy2.13340en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-07-25en
rioxxterms.typeJournal Article/Reviewen


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