Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor
dc.contributor.author | Stichling, N | |
dc.contributor.author | Suomalainen, M | |
dc.contributor.author | Flatt, JW | |
dc.contributor.author | Schmid, M | |
dc.contributor.author | Pacesa, M | |
dc.contributor.author | Hemmi, S | |
dc.contributor.author | Jungraithmayr, W | |
dc.contributor.author | Maler, MD | |
dc.contributor.author | Freudenberg, MA | |
dc.contributor.author | Plückthun, A | |
dc.contributor.author | May, T | |
dc.contributor.author | Köster, M | |
dc.contributor.author | Fejer, Gyorgy | |
dc.contributor.author | Greber, UF | |
dc.date.accessioned | 2018-03-20T11:30:32Z | |
dc.date.available | 2018-03-20T11:30:32Z | |
dc.date.issued | 2018-03 | |
dc.identifier.issn | 1553-7366 | |
dc.identifier.issn | 1553-7374 | |
dc.identifier.other | e1006914 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/11118 | |
dc.description.abstract |
Macrophages are a diverse group of phagocytic cells acting in host protection against stress, injury, and pathogens. Here, we show that the scavenger receptor SR-A6 is an entry receptor for human adenoviruses in murine alveolar macrophage-like MPI cells, and important for production of type I interferon. Scavenger receptors contribute to the clearance of endogenous proteins, lipoproteins and pathogens. Knockout of SR-A6 in MPI cells, anti-SR-A6 antibody or the soluble extracellular SR-A6 domain reduced adenovirus type-C5 (HAdV-C5) binding and transduction. Expression of murine SR-A6, and to a lower extent human SR-A6 boosted virion binding to human cells and transduction. Virion clustering by soluble SR-A6 and proximity localization with SR-A6 on MPI cells suggested direct adenovirus interaction with SR-A6. Deletion of the negatively charged hypervariable region 1 (HVR1) of hexon reduced HAdV-C5 binding and transduction, implying that the viral ligand for SR-A6 is hexon. SR-A6 facilitated macrophage entry of HAdV-B35 and HAdV-D26, two important vectors for transduction of hematopoietic cells and human vaccination. The study highlights the importance of scavenger receptors in innate immunity against human viruses. | |
dc.format.extent | 0-0 | |
dc.format.medium | Electronic-eCollection | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Public Library of Science (PLoS) | |
dc.subject | Adenoviridae Infections | |
dc.subject | Adenoviruses, Human | |
dc.subject | Animals | |
dc.subject | Humans | |
dc.subject | Immunity, Innate | |
dc.subject | Lung | |
dc.subject | Macrophages | |
dc.subject | Macrophages, Alveolar | |
dc.subject | Mice | |
dc.subject | Mice, Inbred BALB C | |
dc.subject | Mice, Inbred C57BL | |
dc.subject | Mice, Knockout | |
dc.subject | Protein Binding | |
dc.subject | Receptors, Immunologic | |
dc.subject | Virus Internalization | |
dc.title | Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000430192300020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 3 | |
plymouth.volume | 14 | |
plymouth.publication-status | Published online | |
plymouth.journal | PLOS Pathogens | |
dc.identifier.doi | 10.1371/journal.ppat.1006914 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/School of Biomedical Sciences | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2018-01-31 | |
dc.identifier.eissn | 1553-7374 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1371/journal.ppat.1006914 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.type | Journal Article/Review | |
plymouth.funder | Establishment of non-transformed, continuously growing, alternatively activated mouse macrophage cell lines::NC3Rs |