Abstract
Angiogenesis is a hallmark of solid tumors, and disruption of tumor vasculature is an active anticancer therapy in some cases. Several proteins expressed on the surface of tumor endothelium have been identified during the last decade. However, due to the expression in both physiological and tumor angiogenesis, only a few targets have been developed for clinical therapeutics. By thorough SAGE analysis of mouse endothelial cells isolated from various normal resting tissues, regenerating liver, and liver-metastasized tumor, Seaman and colleagues in this issue of Cancer Cell have demonstrated organ-specific endothelial markers, physiological angiogenesis endothelial markers, and tumor endothelial markers and revealed striking differences between physiological and pathological angiogenesis.
DOI
10.1016/j.ccr.2007.05.004
Publication Date
2007-06-01
Publication Title
Cancer Cell
Volume
11
Issue
6
Publisher
Elsevier BV
ISSN
1535-6108
Embargo Period
2024-11-19
First Page
478
Last Page
481
Recommended Citation
Li, J., & Harris, A. (2007) 'The Potential of New Tumor Endothelium-Specific Markers for the Development of Antivascular Therapy', Cancer Cell, 11(6), pp. 478-481. Elsevier BV: Available at: https://doi.org/10.1016/j.ccr.2007.05.004
