ORCID

Abstract

Several groups have documented the expression of cytokines in rheumatoid arthritis synovial tissue over the past 15 years or so. These studies have indicated that most cytokines examined are expressed at the mRNA levels at least, and many other cytokines are found in abundance as proteins. Our attention has recently focused on the mechanisms that induce and regulate tumour necrosis factor and IL-10. Other workers and ourselves have found that cell-cell contact is an important signal for the induction of cytokines, and our work has demonstrated that tumour necrosis factor and IL-10 production in rheumatoid arthritis synovial joint cells cultures is dependent on T cell/macrophage interaction. In this chapter, we review recent advances in this area and also highlight areas where new therapeutic intervention opportunities arise.

DOI

10.1186/ar556

Publication Date

2002-01-01

Publication Title

Arthritis Res

ISSN

1465-9905

Organisational Unit

School of Biomedical Sciences

Keywords

Animals, Arthritis, Rheumatoid, Cell Communication, Cytokines, Humans, Macrophages, Signal Transduction, Synovial Membrane, T-Lymphocytes

First Page

S177

Last Page

S182

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