Cytokine regulation in RA synovial tissue: role of T cell/macrophage contact-dependent interactions.
ORCID
- Foey, Andrew: 0000-0003-0419-2268
Abstract
Several groups have documented the expression of cytokines in rheumatoid arthritis synovial tissue over the past 15 years or so. These studies have indicated that most cytokines examined are expressed at the mRNA levels at least, and many other cytokines are found in abundance as proteins. Our attention has recently focused on the mechanisms that induce and regulate tumour necrosis factor and IL-10. Other workers and ourselves have found that cell-cell contact is an important signal for the induction of cytokines, and our work has demonstrated that tumour necrosis factor and IL-10 production in rheumatoid arthritis synovial joint cells cultures is dependent on T cell/macrophage interaction. In this chapter, we review recent advances in this area and also highlight areas where new therapeutic intervention opportunities arise.
DOI
10.1186/ar556
Publication Date
2002-01-01
Publication Title
Arthritis Res
ISSN
1465-9905
Organisational Unit
School of Biomedical Sciences
Keywords
Animals, Arthritis, Rheumatoid, Cell Communication, Cytokines, Humans, Macrophages, Signal Transduction, Synovial Membrane, T-Lymphocytes
First Page
S177
Last Page
S182
Recommended Citation
Brennan, F., & Foey, A. (2002) 'Cytokine regulation in RA synovial tissue: role of T cell/macrophage contact-dependent interactions.', Arthritis Res, , pp. S177-S182. Available at: https://doi.org/10.1186/ar556
