ORCID
- Jackson, Simon: 0000-0002-5475-7637
Abstract
Vitamin D deficiency is a global disorder associated with several chronic illnesses including dyslipidemia and metabolic syndrome. The impact of this association with both dyslipidemia and vitamin D deficiency on metabolomics profile is not yet fully understood. This study analyses the metabolomics and lipidomic signatures in relation to vitamin D status and dyslipidemia. Metabolomics data were collected from Qatar Biobank database and categorized into four groups based on vitamin D and dyslipidemia status. Metabolomics multivariate analysis was performed using the orthogonal partial least square discriminate analysis (OPLS-DA) whilst linear models were used to assess the per-metabolite association with each of the four dyslipidemia/vitamin D combination groups. Our results indicate a high prevalence of vitamin D deficiency among the younger age group, while dyslipidemia was more prominent in the older group. A significant alteration of metabolomics profile was observed among the dyslipidemic and vitamin D deficient individuals in comparison with control groups. These modifications reflected changes in some key pathways including ceramides, diacylglycerols, hemosylceramides, lysophospholipids, phosphatidylcholines, phosphatidylethanol amines, and sphingomyelins. Vitamin D deficiency and dyslipidemia have a deep impact on sphingomyelins profile. The modifications were noted at the level of ceramides and are likely to propagate through downstream pathways.
DOI
10.3390/metabo12080771
Publication Date
2022-08-11
Publication Title
Metabolites
Volume
12
Issue
8
ISSN
2218-1989
Embargo Period
2022-11-01
Organisational Unit
School of Biomedical Sciences
Recommended Citation
Mousa, H., Elrayess, M., Diboun, I., Jackson, S., & Zughaier, S. (2022) 'Metabolomics Profiling of Vitamin D Status in Relation to Dyslipidemia', Metabolites, 12(8). Available at: https://doi.org/10.3390/metabo12080771
