Abstract
Effectiveness in biological chemical environments virtually defines the term 'drug' when applied to any attempt to modify that environment by the introduction of an influence in terms of a specific compound or group of compounds. Interest in the configuration of the molecules involved in such modifications led to the X-ray structure determinations, discussed in the thesis, of the following three compounds: (i) 7-chloro-2-methyl-5-phenyl-3-propyl [2,3-b]-imidazolyl quinoline. Derived from the psychoactive drug Librium, it was thought to conform to the structure, containing the highly strained 4-membered monocyclic azete system (Shenoy, a thesis submitted for the degree of Doctor of Philosophy, University of London, 1975), and suggested as one of the first examples of possible stable 4-membered azacyclobutadiene rings. (ii) The methyl ester of 5,5-dimethyl-2-(2-phenoxymethyl-5-oxo-1,3-oxazolin-4-ylidene)-1,3-thiazolidine-4-carboxylic acid.
Document Type
Thesis
Publication Date
1979-01-01
DOI
10.24382/3828
Recommended Citation
GANE, P. A. (1979) THE STRUCTURAL AND PHYSICAL PROPERTIES OF CRYSTALLINE ANTIBIOTIC MATERIALS. Thesis. University of Plymouth. Available at: https://doi.org/10.24382/3828
