Abstract
Neurotransmitter exocytosis and short-term synaptic plasticity (STSP) regulate large-scale brain electrical activity. This study is the first, to our knowledge, proposing a multiple-time-scale model that bridges between the microscopic and mesoscopic scales. It is parsimonious, yet with enough descriptive power to express, on the one hand, the interactions between the SNARE and Sec1/Munc18 (SM) protein complexes mediating all forms of neurotransmitter release and STSP and, on the other hand, the electrical activity required for neuronal communication. A key finding is the discovery of a mathematical structure, termed activity-induced transcritical canard, which quantifies and explains delayed and irregular exocytosis. This structure also provides a previously unidentified way to understand delayed and irregular processes sensitive to initial conditions across various biology processes.
DOI
10.1073/pnas.1525591113
Publication Date
2016-02-23
Publication Title
Proceedings of the National Academy of Sciences
Volume
113
Issue
8
Publisher
Proceedings of the National Academy of Sciences
ISSN
1091-6490
Embargo Period
2024-11-22
Recommended Citation
Rodrigues, S., Desroches, M., Krupa, M., & et al. (2016) 'Time-coded neurotransmitter release at excitatory and inhibitory synapses', Proceedings of the National Academy of Sciences, 113(8). Proceedings of the National Academy of Sciences: Available at: https://doi.org/10.1073/pnas.1525591113
