Abstract
Asynchronous and spontaneous neurotransmitter release remain elusive and constitute topics of considerable research both from the experimental and modeling perspective. This study proposes a parsimonious model that accounts for all modes of vesicle exocytosis and Short-Term Synaptic Plasticity (STSP). The modeling novelty is based on principles of slow-fast dynamical systems theory. The model's validity is shown by its good agreement with experimental data obtained from in vitro electrophysiological dual whole-cell recordings between local cholecystokinin (CKK)-positive, Schaffer collateral associated (SCA) interneurons in the CA1 region of rat hippocampus~\cite{AfiaAli2007,AfiaAli2010}. These unitary synapses display asynchronous release, governed by the retrograde release of endocannabinoid in response to post-synaptic membrane depolarisation. This work will advance our understanding of the physiology underlying differential exocytosis, and facilitate large-scale neuronal simulations.
Publication Date
2013-08-14
Publisher
University of Plymouth
Embargo Period
2024-11-22
Recommended Citation
Rodrigues, S., Desroches, M., Krupa, M., Cortes, J., & Afia, A. (2013) 'Model for (a)synchronous/spontaneous release, applied to CCK-positive Interneuron synapses', University of Plymouth: Retrieved from https://pearl.plymouth.ac.uk/secam-research/1707
