ORCID
- Pan, Genhua: 0000-0002-2678-7898
Abstract
We report on a label-free immunosensor based on graphene field effect transistors (G-FETs) for the ultrasensitive detection of Human Chorionic Gonadotrophin (hCG), as an indicator of pregnancy and related disorders, such as actopic pregnancy, choriocarcinoma and orchic teratoma. Pyrene based bioactive ester was non-covalently anchored onto the graphene channel in order to retain the sp2 lattice. The G-FET transfer characteristics showed repeatable and reliable responses in all surface modifying steps using a direct current (DC) readout system. The hCG concentration gradient showed a detection limit of ~1 pg·mL−1. The proposed method facilitates the cost-effective and viable production of graphene point-of-care devices for clinical diagnosis.
DOI
10.3390/bios7030027
Publication Date
2017-07-12
Publication Title
Biosensors
Volume
7
Issue
3
Organisational Unit
School of Engineering, Computing and Mathematics
First Page
27
Last Page
27
Recommended Citation
Islam, K., Suhail, A., & Pan, G. (2017) 'A Label-Free and Ultrasensitive Immunosensor for Detection of Human Chorionic Gonadotrophin Based on Graphene FETs', Biosensors, 7(3), pp. 27-27. Available at: https://doi.org/10.3390/bios7030027
