ORCID
- Mullin, Stephen: 0000-0002-1936-394X
Abstract
Mutations in GBA which are causative of Gaucher disease in their biallelic form, are the most common genetic risk factor for Parkinson's disease (PD). The diagnosis of PD relies upon clinically defined motor features which appear after irreversible neurodegeneration. Prodromal symptoms of PD may provide a means to predict latent pathology, years before the onset of motor features. Previous work has reported prodromal features of PD in GBA mutation carriers, however this has been insufficiently sensitive to identify those that will develop PD. The Remote Assessment of Parkinsonism Supporting Ongoing Development of Interventions in Gaucher Disease (RAPSODI GD) study assesses a large cohort of GBA mutation carriers, to aid development of procedures for earlier diagnosis of PD.
DOI
10.2217/nmt-2021-0032
Publication Date
2021-12-01
Publication Title
Neurodegenerative Disease Management
Volume
11
Issue
6
ISSN
1758-2024
Embargo Period
2022-03-09
Organisational Unit
Peninsula Medical School
First Page
451
Last Page
458
Recommended Citation
Higgins, A. L., Toffoli, M., Mullin, S., Lee, C., Koletsi, S., Avenali, M., Blandini, F., & Schapira, A. (2021) 'The remote assessment of parkinsonism supporting the ongoing development of interventions in Gaucher disease', Neurodegenerative Disease Management, 11(6), pp. 451-458. Available at: https://doi.org/10.2217/nmt-2021-0032
