ORCID
- ME Cramp: 0000-0002-1152-0568
Abstract
Background Renal dysfunction post liver transplantation (LT) is common. We report our real-world experience of IL2Ra induction with immediate exposure to reduced dose tacrolimus used for patients with chronic kidney disease (CKD) and evolving acute kidney injury (AKI). Method A single-centre retrospective analysis of elective adult LT from 1/1/17 to 31/12/17. The primary outcome measure was increase in CKD stage at month 6 post-LT, and secondary outcome was early biopsy proven acute rejection (BPAR). Results 161 patients were included: 17 planned-IL2Ra for CKD; 38 unplanned-IL2Ra for AKI; and 106 standard immunosuppression. IL2Ra group had lower trough tacrolimus levels till month 3 post-LT. Patients receiving IL2Ra did not have an increased risk of increase in CKD class at month 6 (aOR 0.95, 95% CI 0.34–2.75, P = 0.92), or of early BPAR (aOR 0.53, 95% CI 0.19–1.32, P = 0.19). Conclusion IL2Ra induction with immediate exposure to reduced dose tacrolimus can be given to patients with CKD or early evolving AKI post-LT, with no greater attrition of renal function at 6 months or an increased risk of early BPAR when compared to standard IS. Longer-term outcome data is required, however this regimen can be considered for high risk LT recipients with CKD and AKI.
DOI Link
DOI
10.1016/j.liver.2021.100028
Publication Date
2021-01-01
Publication Title
Journal of Liver Transplantation
Volume
3
Embargo Period
2022-02-26
Recommended Citation
Nayagam, J., Tavabie, O., Norton, B., McMahon, M., Ramos, K., Cadden, I., Cramp, M., Menon, K., Prachalias, A., Agarwal, K., Heneghan, M., Joshi, D., & Aluvihare, V. (2021) 'Interleukin-2 receptor antibody induction with early low dose tacrolimus preserves post-liver transplant renal function in at risk individuals', Journal of Liver Transplantation, 3. Available at: 10.1016/j.liver.2021.100028
