ORCID
- Roy, Holly: 0000-0002-0691-6605
Abstract
Introduction: ToRCH is an acronym for four congenital infections that are sometimes difficult to distinguish: Toxoplasmosis, Rubella, Cytomegalovirus (CMV), and Herpes Simplex Virus (HSV). This group of organisms produces serious Central Nervous System (CNS) and other infections, which are potentially preventable and treatable. Methods: Neonates and infants with hydrocephalus (N = 65) identified via the outpatient department of the National Institute of Neurosciences and Hospital (NINS&H), were prospectively screened for ToRCH antibodies. Hydrocephalus secondary to Tumor or Trauma was excluded from this study. Results: Evidence of 75.38 % (p = <0.05) patient was positive for TORCH antibodies. Toxoplasma Gondi (T. Gondii) IgG 18.5 % ( p= <0.05 ), CMV IgM 9.2 % (p = <0.05), CMV Ig G47.7% ( p = <0.5), Rubella, and HSV 1 & 2 antibodies were also identified. Conclusion: The vast majority of cases of neonatal hydrocephalus at one institution was post-infectious in etiology and related to ToRCH infections. Many of these cases could be prevented with improved screening and treatment. While study of a single institution may not be the representative of the entire population, further study and implementation of a standardized screening protocol would likely benefit this population. Bang. J Neurosurgery 2020; 9(2): 121-125
DOI
10.3329/bjns.v9i2.44886
Publication Date
2020-01-14
Publication Title
Bangladesh Journal of Neurosurgery
Volume
9
Issue
2
ISSN
2411-6637
Embargo Period
2022-03-08
Organisational Unit
Peninsula Medical School
First Page
121
Last Page
125
Recommended Citation
Mukherjee, S., Arman, D., Roy, H., Khan, R., Afreen, S., Hossain, M., Md, Z., Ekramullah, S., Rahman, M., Yusuf, M., & Islam, M. (2020) 'Status of ToRCH positivity among the children presented with congenital Hydrocephalus', Bangladesh Journal of Neurosurgery, 9(2), pp. 121-125. Available at: https://doi.org/10.3329/bjns.v9i2.44886
