Abstract
Mantle cell lymphoma (MCL) is an aggressive form of non-Hodgkin lymphoma that remains incurable for the majority of patients. Allogeneic stem cell transplantation (alloSCT) produces long-term disease-free remissions for around 30-40% patients, however it is reserved for the treatment of relapsed disease. This study examined the use of front line transplantation for young patients in an attempt to improve outcomes. Twenty-five patients received an alloSCT using BEAM [BCNU (carmustine), etoposide, cytarabine, melphalan)-Campath conditioning following permissive induction therapy from both related and unrelated donors. This was a multi-centre prospective trial. Twenty-four of 25 patients engrafted with no non-relapse mortality events by day 100. With a median follow-up of 60·5 months, there have been six deaths (3 from MCL). The progression-free survival (PFS) and overall survival were 68% and 80% at 2 years and 56% and 76% at 5 years. PFS was very similar for both sibling and unrelated transplants and there was no difference in PFS between patients with respect to remission status prior to transplantation. Nine (38%) patients experienced acute graft-versus-host disease (GVHD) and 14 (58%) experienced chronic GVHD, of which 8 were extensive. Front line alloSCT is feasible but should only be considered for patients at high risk of early progression following conventional therapy.
DOI
10.1111/bjh.15723
Publication Date
2018-12-17
Publication Title
British Journal of Haematology
Publisher
Wiley
ISSN
1365-2141
Embargo Period
2024-11-19
Additional Links
https://www.ncbi.nlm.nih.gov/pubmed/30560573
Keywords
clinical trials, non-Hodgkin lymphoma, stem cell transplantation
Recommended Citation
Rule, S., Cook, G., Russell, N., Hunter, A., & et al. (2018) 'Allogeneic stem cell transplantation as part of front line therapy for Mantle cell lymphoma.', British Journal of Haematology, . Wiley: Available at: https://doi.org/10.1111/bjh.15723
