Abstract

The pharmacokinetics of propofol are relatively well described in the pediatric population. Recent work has confirmed the validity of allometric scaling for predicting propofol disposition across different species and for describing pediatric ontogenesis. In the first year of life, allometric models require adjustment to reflect ontogeny of maturation. Pharmacodynamic data for propofol in children are scarcer, because of practical difficulties in data collection and the limitations of currently available depth of anesthesia monitors for pediatric use. Hence, questions relating to the comparative sensitivity of children to propofol, and differences in time to peak effect relative to adults, remain unanswered. K(eo) half-lives have been determined for pediatric kinetic models using time to peak effect techniques but are not currently incorporated into commercially available target-controlled infusion pumps.

DOI

10.1111/j.1460-9592.2010.03454.x

Publication Date

2011-03-01

Publication Title

Paediatr Anaesth

Volume

21

Issue

3

Organisational Unit

Peninsula Medical School

Keywords

Algorithms, Anesthesia, Intravenous, Anesthetics, Body Weight, Child, Consciousness Monitors, Drug Delivery Systems, Humans, Infant, Newborn, Infusions, Propofol

First Page

247

Last Page

254

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