ORCID
- J. Robert Sneyd: 0000-0003-3546-9856
Abstract
Etomidate is a well established intravenous anaesthetic agent which has been widely used. Recognised limitations of the agent include adrenocortical suppression, myoclonus and post-operative nausea and vomiting, PONV. MOC-etomidate, carboetomidate and MOC-carboetomidate are novel etomidate derivatives. Their preclinical data and their potential for human administration are critically reviewed. 'Soft' pharmacology (rapid ester hydrolysis) limits the duration of action of MOC-etomidate and MOC-carboetomidate giving them rapid offset after administration is discontinued. Adrenocortical depression is minimised either by ester hydrolysis or by structural change to the etomidate molecule. Potential limitations include the yet to be determined incidence of myoclonus and PONV if these new agents are administered to humans.
Publication Date
2012-01-01
Publication Title
Current Pharmaceutical Design
Volume
18
Issue
38
ISSN
1381-6128
Keywords
Carboetomidate, Etomidate, MOC-carboetomidate, MOC-etomidate, Midazolam, Propofol
First Page
6253
Last Page
6256
Recommended Citation
Sneyd, J. (2012) 'Novel etomidate derivatives', Current Pharmaceutical Design, 18(38), pp. 6253-6256. Retrieved from https://pearl.plymouth.ac.uk/more-foh-research/137
