ORCID

Abstract

Objectives: To provide evidence on the responsiveness of social care and well-being preference-based measures (PBMs) compared with health-related quality of life PBMs in the context of multiple sclerosis (MS). Methods: The ICEpop CAPability measure for Adults (ICECAP-A) and Adult Social Care Outcomes Toolkit (ASCOT) were completed online in September 2019, March 2020, September 2020, via the UK MS Register. Responses were linked to EQ-5D-3L and MS Impact Scale-8 Dimensions (MSIS-8D) values, and to MS Walking Scale-12, Hospital Anxiety and Depression Scale (HADS), and Fatigue Severity Scale scores. Responsiveness was assessed in relation to minimal important differences on MS Walking Scale-12, Hospital Anxiety and Depression Scale, and Fatigue Severity Scale between time points, using mean change scores, t tests, standardized effect sizes, standardized response means, and multivariable regression analyses. Results: Data from 1742 people with MS were available for analysis. When using standardized values, MSIS-8D showed the greatest responsiveness and EQ-5D-3L the least. In contrast, when absolute utility values were used, EQ-5D-3L performed similarly to MSIS-8D and better than ICECAP-A and ASCOT. Standardized regression analyses indicated the MSIS-8Ds to be the most responsive, followed by the ASCOT, ICECAP-A, and EQ-5D-3L. Conclusions: The ICECAP-A, ASCOT, and MSIS-8D were more responsive than the EQ-5D-3L in the context of MS when compared using standardized scores. The increased responsiveness of EQ-5D-3L when absolute values were used seems an artefact of the wide-ranging scale of this measure. This illustrates how the maximum potential range of values for a given PBM tariff could influence whether an intervention is found to be cost-effective.

Publication Date

2025-10-14

Publication Title

Value in Health

ISSN

1098-3015

Acceptance Date

2025-09-26

Deposit Date

2025-12-09

Funding

The research reported in this article was funded by the Multiple Sclerosis Society of Great Britain (Grant Code 82). The data were collected by the UK MS Register Project (Ref: 16/SW/0194); the authors acknowledge the contribution of all Members of the UK MS Register Team based at Swansea University Medical School. The authors also thank the Members of the HEMS Patient Involvement Group, and the Members of the MS Register who provided the data used in this study.

Keywords

EQ-5D, health-related quality-of-life measures, preference-based measures, QALY measures, responsiveness, social-care-related quality-of-life measures, well-being measures

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Download

Share

COinS