ORCID
- Jennifer Freeman: 0000-0002-4072-9758
Abstract
Background: There is limited understanding of adherence and compliance rates for exercise training(ET) in people with progressive multiple sclerosis(PMS).Objectives: This secondary, exploratory data analysis examined rates of adherence and compliance for continuous, moderate intensity training and high-intensity intervaltraining(HIIT) and possible correlates among people with PMS from the CogEx trial.Methods: CogEx was a multi-site, multi-arm, randomized, double-blinded, and shamcontrolled trial undertaken by 11 sites in six di8erent countries. Participants(N=311) wererandomized into one of four conditions with di8erent combinations of ET and cognitive rehabilitation, including respective sham conditions, delivered twice weekly over 12 weeks.The analysis focused on adherence and compliance rates and correlates for participants in the pooled ET intervention conditions who received and attempted the ETintervention(n=152).Results: The rates of adherence and compliance overall(combined for both training stimuli) were 94% and 66%, respectively. The rates of adherence and compliance forcontinuous, moderate-intensity exercise were 95% and 73%, respectively, and for HIIT were 92% and 58%, respectively. The multivariable regression indicated that better 6MWTperformance predicted higher compliance(particularly with HITT), whereas better CVLT-II performance predicted higher adherence and compliance with continuous training in PMS.Conclusion: Our results highlight worse compliance than adherence with ET, particularly for HIIT, in PMS. We further highlight cognitive and physical function as correlates ofadherence and compliance for consideration in future clinical trials of ET in PMS.
DOI Link
Publication Date
2025-11-12
Publication Title
Multiple Sclerosis and Related Disorders
Volume
105
ISSN
2211-0348
Acceptance Date
2025-11-11
Deposit Date
2025-12-03
Additional Links
Keywords
Adherence, Behavior change, Compliance, Exercise training, Progressive multiple sclerosis
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
CogEx Research Team., Motl, R., Argie, A., Hernandez, R., Sandroff, B., Amato, M., Brichetto, G., Chataway, J., Chiaravalloti, N., Cutter, G., Dalgas, U., DeLuca, J., Farrell, R., Feys, P., Filippi, M., Freeman, J., Inglese, M., Meza, C., Rocca, M., Salter, A., & Feinstein, A. (2025) 'Adherence and compliance with exercise training in progressive multiple sclerosis: Rates and correlates from the CogEx trial', Multiple Sclerosis and Related Disorders, 105. Available at: 10.1016/j.msard.2025.106859
