ORCID
- Jonathan Marsden: 0000-0002-2037-4902
Abstract
Background Benign paroxysmal positional vertigo (BPPV) affects approximately half of acute, moderate-severe traumatic brain injury (TBI) patients. To date, there have been no rigorous studies of BPPV assessment or treatment in this cohort. We aimed to determine the safety, practicability, and efficacy of therapist-led BPPV management in acute TBI and the feasibility of a larger effectiveness trial. Methods This was a multi-centre, three-arm, parallel-groups, randomised, feasibility trial. Recruitment was via convenience sampling. The main inclusion criteria were age over 18 years and a confirmed, non-penetrating, acute TBI. BPPV-positive patients were randomly allocated to one of three interventions (repositioning manoeuvres, Brandt-Daroff exercises or advice) using minimisation criteria. Outcome assessors were blinded to the intervention. Results Of 2014 patients screened for inclusion, 180 were assessed for BPPV. Of those assessed, 34% (62/180) had BPPV, and 58 patients received an intervention. Therapist-led interventions were delivered safely and accurately according to intervention monitoring criteria. Resolution of BPPV was observed in 35/58 (60%) patients. The resolution rate was highest following repositioning manoeuvres (78%), followed by the advice (53%) and Brandt-Daroff interventions (42%). 10 patients experienced recurrence. This was observed more frequently in those with skull fractures and bilateral or mixed BPPV. Conclusions Overall, the results provide strong evidence for the feasibility of a future trial. Therapist-led management of BPPV in acute TBI was safe and practicable. Repositioning manoeuvres seemingly yielded a superior treatment effect. However, given the high recurrence rate of post-traumatic BPPV, the optimal time to treat according to patients' specific recurrence risk requires further investigation. Trial registration ISRCTN91943864, https://doi.org/10.1186/ISRCTN91943864.
Publication Date
2024-05-29
Publication Title
BMJ Neurology Open
Volume
6
Issue
1
Keywords
NEUROOTOLOGY, RANDOMISED TRIALS, REHABILITATION, TRAUMATIC BRAIN INJURY, VERTIGO
Recommended Citation
Smith, R., Seemungal, B., Burgess, C., Beattie, J., Newdick, A., Tahtis, V., Sahu, B., Golding, J., & Marsden, J. (2024) 'Treating benign paroxysmal positional vertigo in acute traumatic brain injury: A prospective, randomised clinical trial assessing safety, feasibility, and efficacy', BMJ Neurology Open, 6(1). Available at: 10.1136/bmjno-2023-000598
