Abstract
OBJECTIVE: To investigate the stability of epirubicin bladder instillation, prepared from two different epirubicin formulations, under refrigerated storage, transportation and clinical use conditions. METHOD: A sequential study design was used. Epirubicin instillation (1 mg/mL) in polypropylene syringes was sequential incubated for periods of 84 days at 8 degrees C followed by 2 h at 25 degrees C and 1 h at 37 degrees C, the latter two temperatures replicating transport and intravesical conditions, respectively. RESULTS: The instillation was both chemically and physically stable under those incubation conditions. The formulation of epirubicin used to prepare the instillation infusions did not affect stability.
DOI
10.1046/j.0269-4727.2003.00501.x
Publication Date
2003-10-01
Publication Title
J Clin Pharm Ther
Volume
28
Issue
5
First Page
349
Last Page
353
ISSN
0269-4727
Organisational Unit
School of Health Professions
Keywords
Administration, Intravesical, Antibiotics, Antineoplastic, Chemistry, Pharmaceutical, Chromatography, Liquid, Drug Stability, Drug Storage, Epirubicin
Recommended Citation
Sewell, G., Rigby-Jones, A., & Priston, M. (2003) 'Stability of intravesical epirubicin infusion: a sequential temperature study.', J Clin Pharm Ther, 28(5), pp. 349-353. Available at: https://doi.org/10.1046/j.0269-4727.2003.00501.x
