Abstract

OBJECTIVE: To investigate the stability of epirubicin bladder instillation, prepared from two different epirubicin formulations, under refrigerated storage, transportation and clinical use conditions. METHOD: A sequential study design was used. Epirubicin instillation (1 mg/mL) in polypropylene syringes was sequential incubated for periods of 84 days at 8 degrees C followed by 2 h at 25 degrees C and 1 h at 37 degrees C, the latter two temperatures replicating transport and intravesical conditions, respectively. RESULTS: The instillation was both chemically and physically stable under those incubation conditions. The formulation of epirubicin used to prepare the instillation infusions did not affect stability.

Publication Date

2003-01-01

Publication Title

Journal of Clinical Pharmacy and Therapeutics

Volume

28

Issue

5

ISSN

0269-4727

Keywords

Administration, Intravesical, Antibiotics, Antineoplastic, Chemistry, Pharmaceutical, Chromatography, Liquid, Drug Stability, Drug Storage, Epirubicin

First Page

349

Last Page

353

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10.1046/j.0269-4727.2003.00501.x" data-hide-no-mentions="true">

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