Abstract
OBJECTIVE: To investigate the stability of epirubicin bladder instillation, prepared from two different epirubicin formulations, under refrigerated storage, transportation and clinical use conditions. METHOD: A sequential study design was used. Epirubicin instillation (1 mg/mL) in polypropylene syringes was sequential incubated for periods of 84 days at 8 degrees C followed by 2 h at 25 degrees C and 1 h at 37 degrees C, the latter two temperatures replicating transport and intravesical conditions, respectively. RESULTS: The instillation was both chemically and physically stable under those incubation conditions. The formulation of epirubicin used to prepare the instillation infusions did not affect stability.
DOI
10.1046/j.0269-4727.2003.00501.x
Publication Date
2003-10-01
Publication Title
J Clin Pharm Ther
Volume
28
Issue
5
ISSN
0269-4727
Organisational Unit
School of Health Professions
Keywords
Administration, Intravesical, Antibiotics, Antineoplastic, Chemistry, Pharmaceutical, Chromatography, Liquid, Drug Stability, Drug Storage, Epirubicin
First Page
349
Last Page
353
Recommended Citation
Sewell, G., Rigby-Jones, A., & Priston, M. (2003) 'Stability of intravesical epirubicin infusion: a sequential temperature study.', J Clin Pharm Ther, 28(5), pp. 349-353. Available at: https://doi.org/10.1046/j.0269-4727.2003.00501.x
