Show simple item record

dc.contributor.authorMerrison-Hort, Ren
dc.contributor.authorBorisyuk, Ren
dc.date.accessioned2017-05-10T15:47:04Z
dc.date.available2017-05-10T15:47:04Z
dc.date.issued2013en
dc.identifier.issn1662-5188en
dc.identifier.urihttp://hdl.handle.net/10026.1/9220
dc.description.abstract

Experiments in rodent models of Parkinson's disease have demonstrated a prominent increase of oscillatory firing patterns in neurons within the Parkinsonian globus pallidus (GP) which may underlie some of the motor symptoms of the disease. There are two main pathways from the cortex to GP: via the striatum and via the subthalamic nucleus (STN), but it is not known how these inputs sculpt the pathological pallidal firing patterns. To study this we developed a novel neural network model of conductance-based spiking pallidal neurons with cortex-modulated input from STN neurons. Our results support the hypothesis that entrainment occurs primarily via the subthalamic pathway. We find that as a result of the interplay between excitatory input from the STN and mutual inhibitory coupling between GP neurons, a homogeneous population of GP neurons demonstrates a self-organizing dynamical behavior where two groups of neurons emerge: one spiking in-phase with the cortical rhythm and the other in anti-phase. This finding mirrors what is seen in recordings from the GP of rodents that have had Parkinsonism induced via brain lesions. Our model also includes downregulation of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) channels in response to burst firing of GP neurons, since this has been suggested as a possible mechanism for the emergence of Parkinsonian activity. We found that the downregulation of HCN channels provides even better correspondence with experimental data but that it is not essential in order for the two groups of oscillatory neurons to appear. We discuss how the influence of inhibitory striatal input will strengthen our results.

en
dc.format.extent173 - ?en
dc.languageengen
dc.language.isoengen
dc.subjectHCNen
dc.subjectParkinson's diseaseen
dc.subjectdeep-brain stimulationen
dc.subjectdownregulationen
dc.subjectglobus pallidusen
dc.subjectoscillationen
dc.subjectsynchronizationen
dc.titleThe emergence of two anti-phase oscillatory neural populations in a computational model of the Parkinsonian globus pallidus.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/24348374en
plymouth.volume7en
plymouth.publication-statusPublished onlineen
plymouth.journalFront Comput Neuroscien
dc.identifier.doi10.3389/fncom.2013.00173en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA11 Computer Science and Informatics
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Researchers in ResearchFish submission
dc.publisher.placeSwitzerlanden
dcterms.dateAccepted2013-11-12en
dc.rights.embargoperiodNot knownen
rioxxterms.funderBiotechnology and Biological Sciences Research Council
rioxxterms.identifier.projectA neuronal network generating flexible locomotor behaviour in a simple vertebrate: studies on function and embryonic self-assembly
rioxxterms.versionofrecord10.3389/fncom.2013.00173en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2013en
rioxxterms.typeJournal Article/Reviewen
plymouth.funderA neuronal network generating flexible locomotor behaviour in a simple vertebrate: studies on function and embryonic self-assembly::Biotechnology and Biological Sciences Research Councilen
plymouth.funderA neuronal network generating flexible locomotor behaviour in a simple vertebrate: studies on function and embryonic self-assembly::Biotechnology and Biological Sciences Research Councilen


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record


All items in PEARL are protected by copyright law.
Author manuscripts deposited to comply with open access mandates are made available in accordance with publisher policies. Please cite only the published version using the details provided on the item record or document. In the absence of an open licence (e.g. Creative Commons), permissions for further reuse of content should be sought from the publisher or author.
Theme by 
Atmire NV