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dc.contributor.authorLevy, CL
dc.contributor.authorMatthews, GP
dc.contributor.authorLaudone, GM
dc.contributor.authorBeckett, S
dc.contributor.authorTurner, A
dc.contributor.authorSchoelkopf, J
dc.contributor.authorGane, PAC
dc.date.accessioned2017-04-27T17:38:18Z
dc.date.issued2017-04-21
dc.identifier.issn1572-8757
dc.identifier.issn1572-8757
dc.identifier.other4
dc.identifier.urihttp://hdl.handle.net/10026.1/9157
dc.description.abstract

Microporous ‘functionalised’ calcium carbonate (FCC) has potential for use as a carrier for the controlled release of ‘actives’, by permeation and diffusion. We have investigated the nature of the FCC surface and the mechanism of adsorption of two typical actives, namely the anti-inflammatory drug aspirin and the flavour compound vanillin, from chloroform and aqueous ethanolic solutions. There is indirect evidence from the quantitative perturbation of Tóth isotherms that their adsorption is hindered by a stagnant diffusion layer of water trapped in the micro-porosity of the FCC. To complement previous studies of the surface of FCC, it was also tested with the cationic probe benzyltrimethylammonium bromide and the anionic probe sodium 2-naphthalenesulphonate. Experimental procedures were validated by comparison with adsorption onto ground calcium carbonate and high surface area talc.

dc.format.extent603-612
dc.languageen
dc.language.isoen
dc.publisherSpringer Science and Business Media LLC
dc.subjectControlled drug delivery
dc.subjectControlled flavour release
dc.subjectFunctionalised calcium carbonate (FCC)
dc.subjectVanillin
dc.subjectAspirin
dc.titleMechanism of adsorption of actives onto microporous functionalised calcium carbonate (FCC)
dc.typejournal-article
dc.typearticle
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000400185700012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue4
plymouth.volume23
plymouth.publisher-urlhttp://dx.doi.org/10.1007/s10450-017-9880-7
plymouth.publication-statusPublished
plymouth.journalAdsorption
dc.identifier.doi10.1007/s10450-017-9880-7
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Geography, Earth and Environmental Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA07 Earth Systems and Environmental Sciences
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/BEACh
plymouth.organisational-group/Plymouth/Research Groups/Marine Institute
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dcterms.dateAccepted2017-03-07
dc.rights.embargodate2018-4-21
dc.identifier.eissn1572-8757
dc.rights.embargoperiod12 months
rioxxterms.versionofrecord10.1007/s10450-017-9880-7
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2017-04-21
rioxxterms.typeJournal Article/Review


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