Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity
dc.contributor.author | Mindos, T | |
dc.contributor.author | Dun, X-P | |
dc.contributor.author | North, K | |
dc.contributor.author | Doddrell, RDS | |
dc.contributor.author | Schulz, A | |
dc.contributor.author | Edwards, P | |
dc.contributor.author | Russell, J | |
dc.contributor.author | Gray, B | |
dc.contributor.author | Roberts, SL | |
dc.contributor.author | Shivane, A | |
dc.contributor.author | Mortimer, G | |
dc.contributor.author | Pirie, M | |
dc.contributor.author | Zhang, N | |
dc.contributor.author | Pan, D | |
dc.contributor.author | Morrison, H | |
dc.contributor.author | Parkinson, DB | |
dc.date.accessioned | 2017-02-14T16:18:22Z | |
dc.date.available | 2017-02-14T16:18:22Z | |
dc.date.issued | 2017-01-30 | |
dc.identifier.issn | 0021-9525 | |
dc.identifier.issn | 1540-8140 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/8467 | |
dc.description.abstract |
<jats:p>Loss of the Merlin tumor suppressor and activation of the Hippo signaling pathway play major roles in the control of cell proliferation and tumorigenesis. We have identified completely novel roles for Merlin and the Hippo pathway effector Yes-associated protein (YAP) in the control of Schwann cell (SC) plasticity and peripheral nerve repair after injury. Injury to the peripheral nervous system (PNS) causes a dramatic shift in SC molecular phenotype and the generation of repair-competent SCs, which direct functional repair. We find that loss of Merlin in these cells causes a catastrophic failure of axonal regeneration and remyelination in the PNS. This effect is mediated by activation of YAP expression in Merlin-null SCs, and loss of YAP restores axonal regrowth and functional repair. This work identifies new mechanisms that control the regenerative potential of SCs and gives new insight into understanding the correct control of functional nerve repair in the PNS.</jats:p> | |
dc.format.extent | 495-510 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Rockefeller University Press | |
dc.subject | Adaptor Proteins, Signal Transducing | |
dc.subject | Animals | |
dc.subject | Axons | |
dc.subject | Cell Cycle Proteins | |
dc.subject | Cell Proliferation | |
dc.subject | Crush Injuries | |
dc.subject | Disease Models, Animal | |
dc.subject | Female | |
dc.subject | Genotype | |
dc.subject | Hippo Signaling Pathway | |
dc.subject | Male | |
dc.subject | Mice, Knockout | |
dc.subject | Mitogen-Activated Protein Kinases | |
dc.subject | Motor Activity | |
dc.subject | Myelin Sheath | |
dc.subject | Nerve Growth Factors | |
dc.subject | Nerve Regeneration | |
dc.subject | Neurofibromin 2 | |
dc.subject | Neuronal Plasticity | |
dc.subject | Phenotype | |
dc.subject | Phosphoproteins | |
dc.subject | Protein Serine-Threonine Kinases | |
dc.subject | Proto-Oncogene Proteins c-jun | |
dc.subject | Recovery of Function | |
dc.subject | Schwann Cells | |
dc.subject | Sciatic Nerve | |
dc.subject | Sciatic Neuropathy | |
dc.subject | Signal Transduction | |
dc.subject | Time Factors | |
dc.subject | YAP-Signaling Proteins | |
dc.title | Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity | |
dc.type | journal-article | |
dc.type | Article | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/28137778 | |
plymouth.issue | 2 | |
plymouth.volume | 216 | |
plymouth.publication-status | Published online | |
plymouth.journal | Journal of Cell Biology | |
dc.identifier.doi | 10.1083/jcb.201606052 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2016-11-09 | |
dc.rights.embargodate | 2017-07-30 | |
dc.identifier.eissn | 1540-8140 | |
dc.rights.embargoperiod | 6 months | |
rioxxterms.versionofrecord | 10.1083/jcb.201606052 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
rioxxterms.licenseref.startdate | 2017-01-30 | |
rioxxterms.type | Journal Article/Review | |
plymouth.funder | Interaction between Sox-10 and the tumour suppressor Merlin in tumours of the nervous system.::MRC |