Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death
dc.contributor.author | Parkinson, David | |
dc.contributor.author | Bhaskaran A, | |
dc.contributor.author | Dickinson S, | |
dc.contributor.author | Droggiti A, | |
dc.date.accessioned | 2017-01-03T15:18:51Z | |
dc.date.available | 2017-01-03T15:18:51Z | |
dc.date.issued | 2004-03 | |
dc.identifier.issn | 1540-8140 | |
dc.identifier.issn | 1540-8140 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/8175 | |
dc.description | First author on a major paper (chosen as research highlight) examining how Krox-20 co-ordinately controls the proliferation and survival of Schwann cells by regulating the Jun-N-terminal Kinase/cJun pathway. DP designed and directed experiments and co-wrote paper. This paper describes how Krox-20 acts as a master regulator of Schwann cell development. | |
dc.description.abstract |
<jats:p>The transcription factor Krox-20 controls Schwann cell myelination. Schwann cells in Krox-20 null mice fail to myelinate, and unlike myelinating Schwann cells, continue to proliferate and are susceptible to death. We find that enforced Krox-20 expression in Schwann cells cell-autonomously inactivates the proliferative response of Schwann cells to the major axonal mitogen β–neuregulin-1 and the death response to TGFβ or serum deprivation. Even in 3T3 fibroblasts, Krox-20 not only blocks proliferation and death but also activates the myelin genes periaxin and protein zero, showing properties in common with master regulatory genes in other cell types. Significantly, a major function of Krox-20 is to suppress the c-Jun NH2-terminal protein kinase (JNK)–c-Jun pathway, activation of which is required for both proliferation and death. Thus, Krox-20 can coordinately control suppression of mitogenic and death responses. Krox-20 also up-regulates the scaffold protein JNK-interacting protein 1 (JIP-1). We propose this as a possible component of the mechanism by which Krox-20 regulates JNK activity during Schwann cell development.</jats:p> | |
dc.format.extent | 385-394 | |
dc.format.medium | ||
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Rockefeller University Press | |
dc.subject | egr2 | |
dc.subject | JIP-1 | |
dc.subject | neuregulin | |
dc.subject | PNS | |
dc.subject | myelin | |
dc.title | Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000188778500007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 3 | |
plymouth.volume | 164 | |
plymouth.publication-status | Published | |
plymouth.journal | The Journal of Cell Biology | |
dc.identifier.doi | 10.1083/jcb.200307132 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | United States | |
dc.identifier.eissn | 1540-8140 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1083/jcb.200307132 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.type | Journal Article/Review |