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dc.contributor.authorParkinson, DBen
dc.contributor.authorBhaskaran, Aen
dc.contributor.authorArthur-Farraj, Pen
dc.contributor.authorNoon, LAen
dc.contributor.authorWoodhoo, Aen
dc.contributor.authorLloyd, ACen
dc.contributor.authorFeltri, MLen
dc.contributor.authorWrabetz, Len
dc.contributor.authorBehrens, Aen
dc.contributor.authorMirsky, Ren
dc.contributor.authorJessen, KRen

Schwann cell myelination depends on Krox-20/Egr2 and other promyelin transcription factors that are activated by axonal signals and control the generation of myelin-forming cells. Myelin-forming cells remain remarkably plastic and can revert to the immature phenotype, a process which is seen in injured nerves and demyelinating neuropathies. We report that c-Jun is an important regulator of this plasticity. At physiological levels, c-Jun inhibits myelin gene activation by Krox-20 or cyclic adenosine monophosphate. c-Jun also drives myelinating cells back to the immature state in transected nerves in vivo. Enforced c-Jun expression inhibits myelination in cocultures. Furthermore, c-Jun and Krox-20 show a cross-antagonistic functional relationship. c-Jun therefore negatively regulates the myelinating Schwann cell phenotype, representing a signal that functionally stands in opposition to the promyelin transcription factors. Negative regulation of myelination is likely to have significant implications for three areas of Schwann cell biology: the molecular analysis of plasticity, demyelinating pathologies, and the response of peripheral nerves to injury.

dc.format.extent625 - 637en
dc.subjectAnimals, Newbornen
dc.subjectCell Dedifferentiationen
dc.subjectCoculture Techniquesen
dc.subjectCyclic AMPen
dc.subjectDNA-Binding Proteinsen
dc.subjectEarly Growth Response Protein 2en
dc.subjectGanglia, Spinalen
dc.subjectHMGB Proteinsen
dc.subjectMAP Kinase Kinase 7en
dc.subjectMyelin Proteinsen
dc.subjectMyelin Sheathen
dc.subjectOctamer Transcription Factor-6en
dc.subjectProto-Oncogene Proteins c-junen
dc.subjectSOXB1 Transcription Factorsen
dc.subjectSchwann Cellsen
dc.subjectTranscription Factorsen
dc.subjectWallerian Degenerationen
dc.titlec-Jun is a negative regulator of myelination.en
dc.typeJournal Article
plymouth.journalJ Cell Biolen
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Biomedical Research Group
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Biomedical Research Group/RC Reporting Group BRG
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Collaboration for the Advancement of Medical Education Research Assessment
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Neuroscience
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
dc.publisher.placeUnited Statesen
dc.rights.embargoperiodNot knownen
rioxxterms.typeJournal Article/Reviewen

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