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dc.contributor.authorParkinson, DBen
dc.contributor.authorBhaskaran, Aen
dc.contributor.authorArthur-Farraj, Pen
dc.contributor.authorNoon, LAen
dc.contributor.authorWoodhoo, Aen
dc.contributor.authorLloyd, ACen
dc.contributor.authorFeltri, MLen
dc.contributor.authorWrabetz, Len
dc.contributor.authorBehrens, Aen
dc.contributor.authorMirsky, Ren
dc.contributor.authorJessen, KRen
dc.date.accessioned2017-01-03T15:18:18Z
dc.date.available2017-01-03T15:18:18Z
dc.date.issued2008-05-19en
dc.identifier.urihttp://hdl.handle.net/10026.1/8174
dc.description.abstract

Schwann cell myelination depends on Krox-20/Egr2 and other promyelin transcription factors that are activated by axonal signals and control the generation of myelin-forming cells. Myelin-forming cells remain remarkably plastic and can revert to the immature phenotype, a process which is seen in injured nerves and demyelinating neuropathies. We report that c-Jun is an important regulator of this plasticity. At physiological levels, c-Jun inhibits myelin gene activation by Krox-20 or cyclic adenosine monophosphate. c-Jun also drives myelinating cells back to the immature state in transected nerves in vivo. Enforced c-Jun expression inhibits myelination in cocultures. Furthermore, c-Jun and Krox-20 show a cross-antagonistic functional relationship. c-Jun therefore negatively regulates the myelinating Schwann cell phenotype, representing a signal that functionally stands in opposition to the promyelin transcription factors. Negative regulation of myelination is likely to have significant implications for three areas of Schwann cell biology: the molecular analysis of plasticity, demyelinating pathologies, and the response of peripheral nerves to injury.

en
dc.format.extent625 - 637en
dc.languageengen
dc.language.isoengen
dc.subjectAnimalsen
dc.subjectAnimals, Newbornen
dc.subjectCell Dedifferentiationen
dc.subjectCoculture Techniquesen
dc.subjectCyclic AMPen
dc.subjectDNA-Binding Proteinsen
dc.subjectDown-Regulationen
dc.subjectEarly Growth Response Protein 2en
dc.subjectGanglia, Spinalen
dc.subjectHMGB Proteinsen
dc.subjectMAP Kinase Kinase 7en
dc.subjectMiceen
dc.subjectMyelin Proteinsen
dc.subjectMyelin Sheathen
dc.subjectOctamer Transcription Factor-6en
dc.subjectPhosphorylationen
dc.subjectProto-Oncogene Proteins c-junen
dc.subjectRatsen
dc.subjectSOXB1 Transcription Factorsen
dc.subjectSchwann Cellsen
dc.subjectTranscription Factorsen
dc.subjectUp-Regulationen
dc.subjectWallerian Degenerationen
dc.titlec-Jun is a negative regulator of myelination.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/18490512en
plymouth.issue4en
plymouth.volume181en
plymouth.publication-statusPublisheden
plymouth.journalJ Cell Biolen
dc.identifier.doi10.1083/jcb.200803013en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 All current users
plymouth.organisational-group/Plymouth/00 All current users/Academics
plymouth.organisational-group/Plymouth/00 All current users/Academics/Plymouth University Peninsula School of Medicine and Dentistry
plymouth.organisational-group/Plymouth/00 All current users/Academics/Plymouth University Peninsula School of Medicine and Dentistry/PUPSMD - not in Schools
plymouth.organisational-group/Plymouth/Plymouth University Peninsula Schools of Medicine and Dentistry
plymouth.organisational-group/Plymouth/Plymouth University Peninsula Schools of Medicine and Dentistry/Biomedical Research Group
plymouth.organisational-group/Plymouth/Plymouth University Peninsula Schools of Medicine and Dentistry/Biomedical Research Group/RC Reporting Group BRG
plymouth.organisational-group/Plymouth/Plymouth University Peninsula Schools of Medicine and Dentistry/Neuroscience
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
dc.publisher.placeUnited Statesen_US
dc.publisher.placeUnited Statesen
dc.publisher.placeUnited Statesen
dc.publisher.placeUnited Statesen
dc.publisher.placeUnited Statesen
dc.publisher.placeUnited Statesen
dc.publisher.placeUnited Statesen
dc.publisher.placeUnited Statesen
dc.publisher.placeUnited Statesen
dc.identifier.eissn1540-8140en
rioxxterms.versionofrecord10.1083/jcb.200803013en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2008-05-19en
rioxxterms.typeJournal Article/Reviewen


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