c-Jun is a negative regulator of myelination
dc.contributor.author | Parkinson, DB | |
dc.contributor.author | Bhaskaran, A | |
dc.contributor.author | Arthur-Farraj, P | |
dc.contributor.author | Noon, LA | |
dc.contributor.author | Woodhoo, A | |
dc.contributor.author | Lloyd, AC | |
dc.contributor.author | Feltri, ML | |
dc.contributor.author | Wrabetz, L | |
dc.contributor.author | Behrens, A | |
dc.contributor.author | Mirsky, R | |
dc.contributor.author | Jessen, KR | |
dc.date.accessioned | 2017-01-03T15:18:18Z | |
dc.date.available | 2017-01-03T15:18:18Z | |
dc.date.issued | 2008-05-19 | |
dc.identifier.issn | 0021-9525 | |
dc.identifier.issn | 1540-8140 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/8174 | |
dc.description.abstract |
<jats:p>Schwann cell myelination depends on Krox-20/Egr2 and other promyelin transcription factors that are activated by axonal signals and control the generation of myelin-forming cells. Myelin-forming cells remain remarkably plastic and can revert to the immature phenotype, a process which is seen in injured nerves and demyelinating neuropathies. We report that c-Jun is an important regulator of this plasticity. At physiological levels, c-Jun inhibits myelin gene activation by Krox-20 or cyclic adenosine monophosphate. c-Jun also drives myelinating cells back to the immature state in transected nerves in vivo. Enforced c-Jun expression inhibits myelination in cocultures. Furthermore, c-Jun and Krox-20 show a cross-antagonistic functional relationship. c-Jun therefore negatively regulates the myelinating Schwann cell phenotype, representing a signal that functionally stands in opposition to the promyelin transcription factors. Negative regulation of myelination is likely to have significant implications for three areas of Schwann cell biology: the molecular analysis of plasticity, demyelinating pathologies, and the response of peripheral nerves to injury.</jats:p> | |
dc.format.extent | 625-637 | |
dc.format.medium | ||
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | Rockefeller University Press | |
dc.subject | Animals | |
dc.subject | Animals, Newborn | |
dc.subject | Cell Dedifferentiation | |
dc.subject | Coculture Techniques | |
dc.subject | Cyclic AMP | |
dc.subject | DNA-Binding Proteins | |
dc.subject | Down-Regulation | |
dc.subject | Early Growth Response Protein 2 | |
dc.subject | Ganglia, Spinal | |
dc.subject | HMGB Proteins | |
dc.subject | MAP Kinase Kinase 7 | |
dc.subject | Mice | |
dc.subject | Myelin Proteins | |
dc.subject | Myelin Sheath | |
dc.subject | Octamer Transcription Factor-6 | |
dc.subject | Phosphorylation | |
dc.subject | Proto-Oncogene Proteins c-jun | |
dc.subject | Rats | |
dc.subject | SOXB1 Transcription Factors | |
dc.subject | Schwann Cells | |
dc.subject | Transcription Factors | |
dc.subject | Up-Regulation | |
dc.subject | Wallerian Degeneration | |
dc.title | c-Jun is a negative regulator of myelination | |
dc.type | journal-article | |
dc.type | Article | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/18490512 | |
plymouth.issue | 4 | |
plymouth.volume | 181 | |
plymouth.publication-status | Published | |
plymouth.journal | The Journal of Cell Biology | |
dc.identifier.doi | 10.1083/jcb.200803013 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | United States | |
dc.identifier.eissn | 1540-8140 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1083/jcb.200803013 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.type | Journal Article/Review |