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dc.contributor.authorVolkovova, Ken
dc.contributor.authorHandy, RDen
dc.contributor.authorStaruchova, Men
dc.contributor.authorTulinska, Jen
dc.contributor.authorKebis, Aen
dc.contributor.authorPribojova, Jen
dc.contributor.authorUlicna, Oen
dc.contributor.authorKucharská, Jen
dc.contributor.authorDusinska, Men
dc.date.accessioned2016-06-22T15:52:42Z
dc.date.available2016-06-22T15:52:42Z
dc.date.issued2015-05en
dc.identifier.urihttp://hdl.handle.net/10026.1/4941
dc.description.abstract

The study determined the effect of intravenous administration of acutely toxic or sub-lethal doses of Na-oleate-coated Fe3O4 (OC-Fe3O4) nanoparticles (NPs) on liver structure and function in Wistar rats, compared to titanium dioxide (TiO2) NPs and saline-injected controls. The acute study, using a modified OECD 425 progressive dosing procedure, found LD50 values of 59.22 and 36.42 mg/kg for TiO2 and OC-Fe3O4 NPs, respectively. In the sub-lethal study, rats were either injected with saline (negative controls), a sub-lethal reference (0.592 mg/kgTiO2 NPs, equal to 1% of LD50 on a body weight basis) or OC-Fe3O4 NPs in doses equivalent to 0.1, 1 or 10% of the LD50, respectively (corresponding to 0.0364, 0.364 and 3.64 mg Fe3O4/kg body weight). Animals were sampled 24 h, 1, 2 and 4 weeks post-injection for adverse effects. Mitochondrial respiration was significantly increased 2 weeks after injection of 10% OC-Fe3O4 NPs compared to controls, but the effect was transient. Cholesterol and triacylglycerol concentrations in the liver tissue did not increase in any treatment. There were some disturbances to antioxidant enzymes after OC-Fe3O4 NPs treatment in the livers of animals 1 week post-exposure; with the most sensitive changes occurring in glutathione peroxidase (GPx) and glutathione S-transferase (GST) activities. Lipidosis and mild necrosis with changes in sinusoid space were also observed in histological sections of the liver. Overall, these data suggest that the liver likely retains functional integrity with acute and sub-lethal doses of OC-Fe3O4 NPs, albeit with some stimulation of redox defences and evidence of some tissue injury.

en
dc.format.extent95 - 105en
dc.languageengen
dc.language.isoengen
dc.subjectNa-oleate-coated Fe3O4en
dc.subjectTiO2 nanoparticlesen
dc.subjectin vivo nanotoxicologyen
dc.subjectliver toxicityen
dc.subjectAnimalsen
dc.subjectAntioxidantsen
dc.subjectFerric Compoundsen
dc.subjectGlutathione Peroxidaseen
dc.subjectGlutathione Transferaseen
dc.subjectInjections, Intravenousen
dc.subjectLiveren
dc.subjectMaleen
dc.subjectMitochondriaen
dc.subjectNanoparticlesen
dc.subjectNecrosisen
dc.subjectOleic Aciden
dc.subjectOxidative Stressen
dc.subjectRatsen
dc.subjectTitaniumen
dc.titleHealth effects of selected nanoparticles in vivo: liver function and hepatotoxicity following intravenous injection of titanium dioxide and Na-oleate-coated iron oxide nanoparticles in rodents.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/23763576en
plymouth.volume9 Suppl 1en
plymouth.publication-statusPublisheden
plymouth.journalNanotoxicologyen
dc.identifier.doi10.3109/17435390.2013.815285en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Biological and Marine Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA06 Agriculture, Veterinary and Food Science
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Marine Institute
dc.publisher.placeEnglanden
dc.identifier.eissn1743-5404en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.3109/17435390.2013.815285en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.typeJournal Article/Reviewen


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