A sequential temperature cycling study for the investigation of carboplatin infusion stability to facilitate dose-banding
dc.contributor.author | Sewell, GJ | |
dc.contributor.author | Kaestner, S | |
dc.date.accessioned | 2015-10-27T16:24:42Z | |
dc.date.available | 2015-10-27T16:24:42Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 1078-1552 | |
dc.identifier.issn | 1477-092X | |
dc.identifier.uri | http://hdl.handle.net/10026.1/3713 | |
dc.description.abstract |
<jats:p> Study objective. To determine the physical and chemical stability of carboplatin infusion for dosebanding, with cycling between refrigerated storage and room temperature in-use conditions. </jats:p><jats:p> Design. A sequential study design was selected to closely simulate the temperatures and conditions experienced by drug infusions in pharmaceutical storage and in clinical use. Carboplatin infusions, 0.70 and 2.15 mg/mL, were stored refrigerated for up to 84 days, followed by incubation at 258C for 24 h. The infusions were also returned to refrigerated storage for 3 and 7 days, to replicate a situation in which returned, unused infusions are kept for re-issuing. On pre-determined time-points, infusion chemical and physical stability were determined by HLPC, sub-visual particulatecounts, pH-measurement, and weighing of infusions. </jats:p><jats:p> Results. Light protected carboplatin infusions at both study concentrations were chemically and physically stable following refrigerated storage for 84 days, followed by a further 24 h under ‘in-use’ conditions at 258C. Additionally, the infusions were stable following return to refrigerated storage again for at least 7 days. </jats:p><jats:p> Conclusion. This study has demonstrated extended stability of carboplatin infusions which enables batch-scale preparation of standard infusions for dose- J Oncol Pharm Practice (2007) 13: 119–126. </jats:p> | |
dc.format.extent | 119-126 | |
dc.format.medium | ||
dc.language | en | |
dc.language.iso | en | |
dc.publisher | SAGE Publications | |
dc.subject | Antineoplastic Agents | |
dc.subject | Carboplatin | |
dc.subject | Chromatography, High Pressure Liquid | |
dc.subject | Drug Compounding | |
dc.subject | Drug Packaging | |
dc.subject | Drug Stability | |
dc.subject | Drug Storage | |
dc.subject | Glucose | |
dc.subject | Hydrogen-Ion Concentration | |
dc.subject | Infusions, Intravenous | |
dc.subject | Light | |
dc.subject | Temperature | |
dc.title | A sequential temperature cycling study for the investigation of carboplatin infusion stability to facilitate dose-banding | |
dc.type | journal-article | |
dc.type | Article | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/17873112 | |
plymouth.issue | 2 | |
plymouth.volume | 13 | |
plymouth.publication-status | Published | |
plymouth.journal | Journal of Oncology Pharmacy Practice | |
dc.identifier.doi | 10.1177/1078155207080803 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy MANUAL | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Health and Community | |
plymouth.organisational-group | /Plymouth/Users by role | |
dc.publisher.place | England | |
dc.identifier.eissn | 1477-092X | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1177/1078155207080803 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.type | Journal Article/Review |