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dc.contributor.authorVyas, Nen
dc.contributor.authorYiannakis, Den
dc.contributor.authorTurner, Aen
dc.contributor.authorSewell, GJen
dc.date.accessioned2015-10-27T16:11:34Z
dc.date.available2015-10-27T16:11:34Z
dc.date.issued2014-08en
dc.identifier.urihttp://hdl.handle.net/10026.1/3704
dc.description.abstract

Because anti-cancer drugs are non-selective, they affect both cancerous and non-cancerous cells. Being carcinogenic and mutagenic, many anticancer drugs therefore present a major health risk to healthcare staff working with them. This paper reviews the means by which exposure to anti-cancer drugs in the workplace may be monitored, assessed and reduced. Both biological monitoring, using non-selective methods or compound-selective methods, and environmental monitoring have provided information on the nature and degree of exposure in the workplace. Pharmaceutical isolators, used for the compounding of cytotoxic IV infusions and the preparation of injectable drugs, provide a physical barrier between pharmacists and cytotoxic drugs and reduce direct exposure. However, the interior of isolators and the contents thereof (e.g. infusion bags and syringes) are readily contaminated by aerosols and spillages and afford a secondary source of exposure to pharmacists, nurses and cleaning staff. Closed system transfer devices (CSTDs), designed to prohibit the transfer of contaminants into the working environment during drug transfer between the vial and syringe, have been successful in further reducing, but not eliminating surface contamination. Given that the number of patients requiring treatment with chemotherapeutic agents is predicted to increase, further efforts to reduce occupational exposure to anti-cancer drugs, including the refinement and wider use of CTSDs, are recommended.

en
dc.format.extent278 - 287en
dc.languageengen
dc.language.isoengen
dc.subjectAnti-cancer drugsen
dc.subjectbiological monitoringen
dc.subjectclosed system drug transfer deviceen
dc.subjectenvironmental monitoringen
dc.subjectpharmaceutical isolatoren
dc.subjectAntineoplastic Agentsen
dc.subjectEnvironmental Monitoringen
dc.subjectHumansen
dc.subjectOccupational Exposureen
dc.subjectPharmacistsen
dc.subjectPharmacyen
dc.subjectPharmacy Service, Hospitalen
dc.subjectProtective Devicesen
dc.subjectWorkplaceen
dc.titleOccupational exposure to anti-cancer drugs: A review of effects of new technology.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/23975555en
plymouth.issue4en
plymouth.volume20en
plymouth.publication-statusPublisheden
plymouth.journalJ Oncol Pharm Practen
dc.identifier.doi10.1177/1078155213498630en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Health and Human Sciences
plymouth.organisational-group/Plymouth/Faculty of Health and Human Sciences/School of Health Professions
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Geography, Earth and Environmental Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA07 Earth Systems and Environmental Sciences
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/BEACh
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Research Groups/Marine Institute
dc.publisher.placeEnglanden
dc.identifier.eissn1477-092Xen
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1177/1078155213498630en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.typeJournal Article/Reviewen


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