Preliminary Data on Free Use of Fruits and Vegetables Containing Phenylalanine 76–100 mg/100 g of Food in 16 Children with Phenylketonuria: 6 Months Follow-Up
dc.contributor.author | Pinto, A | |
dc.contributor.author | Daly, A | |
dc.contributor.author | Rocha, JC | |
dc.contributor.author | Ashmore, C | |
dc.contributor.author | Evans, S | |
dc.contributor.author | Jackson, R | |
dc.contributor.author | Hickson, M | |
dc.contributor.author | MacDonald, A | |
dc.date.accessioned | 2023-09-04T10:31:13Z | |
dc.date.available | 2023-09-04T10:31:13Z | |
dc.date.issued | 2023-07-06 | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.other | 3046 | |
dc.identifier.uri | https://pearl.plymouth.ac.uk/handle/10026.1/21281 | |
dc.description.abstract |
<jats:p>In phenylketonuria (PKU), a previous intervention study assessing the patients ability to tolerate fruits and vegetables containing phenylalanine 76–100 mg/100 g without limit or measurement, found that an extra 50 mg/day phenylalanine, but not 100 mg/day, was tolerated from these fruits and vegetables. In a further 6-month extension study, we examined the effect of the ‘free’ use of this group of fruits and vegetables on blood phenylalanine control. For 6 months, the patients ate fruits and vegetables containing phenylalanine 76–100 mg/100 g without limit or measurement. Three-day diet diaries and the patients’ weights were collected monthly. Blood phenylalanine spots were collected weekly aiming for blood phenylalanine levels <360 μmol/L. Retrospective blood phenylalanine was collected 6 months pre-trial. All 16 patients (69% females) from the intervention study took part in the extension study. Most of the patients (n = 14/16) had classical PKU with a median age of 10.5 years (range: 6–13). There was no statistically significant difference in the median blood phenylalanine pre-study (270, range: 50–760 μmol/L) compared to the 6-month extension study (250, range: 20–750 μmol/L) (p= 0.4867). The patients had a median of 21 and 22 bloodspots, pre- and post-trial, respectively. In the extension study, the patients had an actual mean intake of 11 g/day (4–37) natural protein and 65 g/day (60–80) protein equivalent from a protein substitute. The mean phenylalanine intake was 563 mg/day (200–1850) with only 19 mg/day (0–146) phenylalanine from fruits and vegetables containing phenylalanine 76–100 mg/100 g. The weight z-scores remained unchanged (1.52 vs. 1.60, p = 0.4715). There was no adverse impact on blood phenylalanine control when fruits and vegetables containing phenylalanine 76–100 mg/100 g were eaten without limit or measurement. However, the fruits and vegetable portion sizes eaten were small (60 g/week). Further longitudinal work is necessary to examine the ‘free’ use of fruits and vegetables containing phenylalanine 76–100 mg/100 g on metabolic control in patients with PKU.</jats:p> | |
dc.format.extent | 3046-3046 | |
dc.format.medium | Electronic | |
dc.language | en | |
dc.publisher | MDPI | |
dc.subject | phenylketonuria | |
dc.subject | fruits | |
dc.subject | vegetables | |
dc.subject | metabolic control | |
dc.subject | phenylalanine | |
dc.title | Preliminary Data on Free Use of Fruits and Vegetables Containing Phenylalanine 76–100 mg/100 g of Food in 16 Children with Phenylketonuria: 6 Months Follow-Up | |
dc.type | journal-article | |
dc.type | Article | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/37447372 | |
plymouth.issue | 13 | |
plymouth.volume | 15 | |
plymouth.publication-status | Published online | |
plymouth.journal | Nutrients | |
dc.identifier.doi | 10.3390/nu15133046 | |
plymouth.organisational-group | |Plymouth | |
plymouth.organisational-group | |Plymouth|Research Groups | |
plymouth.organisational-group | |Plymouth|Faculty of Health | |
plymouth.organisational-group | |Plymouth|Faculty of Health|School of Health Professions | |
plymouth.organisational-group | |Plymouth|Research Groups|Institute of Health and Community | |
plymouth.organisational-group | |Plymouth|REF 2021 Researchers by UoA | |
plymouth.organisational-group | |Plymouth|Users by role | |
plymouth.organisational-group | |Plymouth|Users by role|Academics | |
plymouth.organisational-group | |Plymouth|REF 2021 Researchers by UoA|UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | |Plymouth|Research Groups|Plymouth Institute of Health and Care Research (PIHR) | |
dc.publisher.place | Switzerland | |
dcterms.dateAccepted | 2023-06-30 | |
dc.date.updated | 2023-09-04T10:31:08Z | |
dc.rights.embargodate | 2023-9-6 | |
dc.identifier.eissn | 2072-6643 | |
dc.rights.embargoperiod | forever | |
rioxxterms.versionofrecord | 10.3390/nu15133046 |