Preliminary development of a questionnaire to measure the extra-pulmonary symptoms of severe asthma
dc.contributor.author | de Felice, G | |
dc.contributor.author | Hyland, ME | |
dc.contributor.author | Lanario, Joseph | |
dc.contributor.author | Antonacci, Y | |
dc.contributor.author | Jones, Rupert | |
dc.contributor.author | Masoli, M | |
dc.date.accessioned | 2023-02-20T12:58:35Z | |
dc.date.issued | 2021-12 | |
dc.identifier.issn | 1471-2466 | |
dc.identifier.issn | 1471-2466 | |
dc.identifier.other | 369 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/20468 | |
dc.description.abstract |
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Research into the effects of asthma treatments on the extra-pulmonary symptoms of severe asthma is limited by the absence of a suitable questionnaire. The aim was to create a questionnaire suitable for intervention studies by selecting symptoms that are statistically associated with asthma pathology and therefore may improve when pathology is reduced. </jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Patients attending a specialist asthma clinic completed the 65-item General Symptom Questionnaire (GSQ-65), a questionnaire validated for assessing symptoms of people with multiple medically unexplained symptoms. Lung function (FEV1%) and cumulative oral corticosteroids (OCS) calculated from maintenance dose plus exacerbations were obtained from clinic records. Pathology was represented by the two components of a principal component analysis (PCA) of FEV1% and OCS. LASSO regression was used to select symptoms that had high coefficients with these two principal components and occurred frequently in severe asthma.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>100 patients provided data. PCA revealed two components, one where FEV1% and OCS were inversely related and another where they were directly related. LASSO regression revealed 39 symptoms with non-zero coefficients on one or more of the two principal components from which 16 symptoms were selected for the GSQ-A on the basis of magnitude of coefficient and frequency. Asthma symptoms measured by asthma control questionnaires were excluded. The GSQ-A correlated 0.33 and − 0.34 (<jats:italic>p</jats:italic> = 0.001) with the two principal components.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>The GSQ-A assesses the frequency of 16 heterogenous non-respiratory symptoms that are associated with asthma severity using the statistical combination of FEV1% and OCS.</jats:p> </jats:sec> | |
dc.format.extent | 369- | |
dc.format.medium | Electronic | |
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.subject | Asthma | |
dc.subject | Symptoms | |
dc.subject | Fibromyalgia | |
dc.subject | Questionnaire | |
dc.subject | Patient reported outcomes | |
dc.title | Preliminary development of a questionnaire to measure the extra-pulmonary symptoms of severe asthma | |
dc.type | journal-article | |
dc.type | Journal Article | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000718272500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 1 | |
plymouth.volume | 21 | |
plymouth.publication-status | Published | |
plymouth.journal | BMC Pulmonary Medicine | |
dc.identifier.doi | 10.1186/s12890-021-01730-0 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy MANUAL | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Centre for Brain, Cognition and Behaviour (CBCB) | |
plymouth.organisational-group | /Plymouth/Research Groups/Centre for Brain, Cognition and Behaviour (CBCB)/Behaviour | |
plymouth.organisational-group | /Plymouth/Research Groups/FoH - Community and Primary Care | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Health and Community | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CCT&PS | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Post-Graduate Research Students | |
dc.publisher.place | England | |
dcterms.dateAccepted | 2021-11-02 | |
dc.rights.embargodate | 2023-2-21 | |
dc.identifier.eissn | 1471-2466 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1186/s12890-021-01730-0 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2021-11-14 | |
rioxxterms.type | Journal Article/Review |