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dc.contributor.authorMroczkowska, S
dc.contributor.authorShokr, H
dc.contributor.authorBenavente-Perez, A
dc.contributor.authorNegi, A
dc.contributor.authorBentham, P
dc.contributor.authorGherghel, D
dc.date.accessioned2022-11-13T13:36:26Z
dc.date.issued2022-11-12
dc.identifier.issn2077-0383
dc.identifier.issn2077-0383
dc.identifier.otherARTN 6702
dc.identifier.urihttp://hdl.handle.net/10026.1/19962
dc.description.abstract

Purpose: To assess the similarities and differences in retinal microvascular function between mild Alzheimer’s disease (AD) patients, early-stage primary open angle glaucoma (POAG) patients and healthy controls. Methods: Retinal vessel reactivity to flickering light was assessed in 10 AD, 19 POAG and 20 healthy age matched control patients by means of dynamic retinal vessel analysis (DVA, IMEDOS, GmbH, Jena, Germany) according to an established protocol. All patients additionally underwent BP measurements and blood analysis for glucose and lipid metabolism markers. Results: AD and POAG patients demonstrated comparable alterations in retinal artery reactivity, in the form of an increased arterial reaction time (RT) to flicker light on the final flicker cycle (p = 0.009), which was not replicated by healthy controls (p > 0.05). Furthermore, the sequential changes in RT on progressing from flicker one to flicker three were found to differ between healthy controls and the two disease groups (p = 0.001). Conclusion: AD and POAG patients demonstrate comparable signs of vascular dysfunction in their retinal arteries at the early stages of their disease process. This provides support for the concept of a common underlying vascular aetiology in these two neurodegenerative diseases.

dc.format.extent6702-6702
dc.format.mediumElectronic
dc.languageen
dc.language.isoen
dc.publisherMDPI
dc.subjectAlzheimer's disease
dc.subjectglaucoma
dc.subjectretinal vessel analysis
dc.subjectvascular dysfunction
dc.titleRetinal Microvascular Dysfunction Occurs Early and Similarly in Mild Alzheimer’s Disease and Primary-Open Angle Glaucoma Patients
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36431179
plymouth.issue22
plymouth.volume11
plymouth.publisher-urlhttps://www.mdpi.com/2077-0383/11/22/6702
plymouth.publication-statusPublished online
plymouth.journalJournal of Clinical Medicine
dc.identifier.doi10.3390/jcm11226702
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Health Professions
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeSwitzerland
dcterms.dateAccepted2022-11-11
dc.rights.embargodate2022-11-15
dc.identifier.eissn2077-0383
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.3390/jcm11226702
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review


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