Bone health, intellectual disability and epilepsy: An observational community‐based study
dc.contributor.author | Winterhalder, R | |
dc.contributor.author | McCabe, J | |
dc.contributor.author | Young, C | |
dc.contributor.author | Lamb, K | |
dc.contributor.author | Sawhney, I | |
dc.contributor.author | Jory, C | |
dc.contributor.author | O'Dwyer, M | |
dc.contributor.author | Shankar, Rohit | |
dc.date.accessioned | 2022-03-20T10:26:34Z | |
dc.date.available | 2022-03-20T10:26:34Z | |
dc.date.issued | 2022-06 | |
dc.identifier.issn | 0001-6314 | |
dc.identifier.issn | 1600-0404 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/18961 | |
dc.description.abstract |
OBJECTIVES: Intellectual disability (ID) and epilepsy are independent risk factors for osteoporosis. Diverse predisposing factors influence this, for example in ID, genetics and poor nutrition and in epilepsy, anti-seizure medication (ASM). Around 25% people with ID have epilepsy, majority treatment resistant. ASMs polypharmacy is common. However, little is known about the bone-related characteristics of this vulnerable group. A prospective observational cohort study of bone profile across a community ID Epilepsy service was undertaken to understand this. MATERIALS & METHODS: Participants were on minimum 2 years of ASMs. Baseline demographics, epilepsy data, bone metabolism biomarkers, bone mineral density (BMD) and vitamin D levels were collected. Doses needed to correct vitamin D insufficiency/deficiency were calculated. RESULTS: At baseline, of 104 participants, 92 (90.2%) were vitamin D insufficient/deficient. Seventy-six (73.1%) had a DEXA scan, 50 of whom-in the osteopaenic/osteoporotic range. DEXA scores between ambulant and non-ambulant patients were significantly different (p = .05) but not for ID severity. A high alkaline phosphatase (ALP) predicted lower vitamin D levels. Borderline significance (p = .06) in calcium levels between normal and high ALP was identified. There were no significant associations between parathyroid hormone, inorganic phosphate and magnesium levels, with vitamin D status or DEXA hip T-scores. Normalizing vitamin D levels (mean 101.4 nmol/L) required an average of 1951IU cholecalciferol daily. CONCLUSIONS: Vitamin D deficiency is highly prevalent in people with ID and epilepsy treated with ASMs impacting likely on their bone health. Screening with vitamin D levels, ALP and DEXA in this group should be pro-actively and routinely considered. | |
dc.format.extent | 753-761 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | Hindawi Limited | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | antiepileptic drugs | |
dc.subject | developmental neurology | |
dc.subject | quality of life | |
dc.subject | seizures | |
dc.subject | treatment | |
dc.title | Bone health, intellectual disability and epilepsy: An observational community‐based study | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Observational Study | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000780437300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 6 | |
plymouth.volume | 145 | |
plymouth.publication-status | Published | |
plymouth.journal | Acta Neurologica Scandinavica | |
dc.identifier.doi | 10.1111/ane.13612 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Users by role | |
dc.publisher.place | Denmark | |
dcterms.dateAccepted | 2022-03-06 | |
dc.rights.embargodate | 9999-12-31 | |
dc.identifier.eissn | 1600-0404 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1111/ane.13612 | |
rioxxterms.licenseref.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
rioxxterms.licenseref.startdate | 2022-03-17 | |
rioxxterms.type | Journal Article/Review |