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dc.contributor.authorSandroff, BMen
dc.contributor.authorMotl, RWen
dc.contributor.authorAmato, MPen
dc.contributor.authorBrichetto, Gen
dc.contributor.authorChataway, Jen
dc.contributor.authorChiaravalloti, NDen
dc.contributor.authorCutter, GRen
dc.contributor.authorDalgas, Uen
dc.contributor.authorDeLuca, Jen
dc.contributor.authorFarrell, Ren
dc.contributor.authorFeys, Pen
dc.contributor.authorFilippi, Men
dc.contributor.authorFreeman, Jen
dc.contributor.authorInglese, Men
dc.contributor.authorMeza, Cen
dc.contributor.authorRocca, MAen
dc.contributor.authorSalter, Aen
dc.contributor.authorFeinstein, Aen

<jats:sec><jats:title>Background:</jats:title><jats:p> Aerobic exercise training (physical activity for improving cardiorespiratory fitness) represents a promising approach for managing cognitive impairment in multiple sclerosis (MS). However, there is limited evidence that levels of physical activity and fitness are associated with cognition in progressive MS. </jats:p></jats:sec><jats:sec><jats:title>Objective:</jats:title><jats:p> We examined associations among cardiorespiratory fitness, moderate-to-vigorous physical activity (MVPA), and cognitive performance in a large, international progressive MS sample. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> Two hundred forty European and North American persons with progressive MS underwent cardiorespiratory fitness measurement on a recumbent stepper, wore an ActiGraph GT3X + accelerometer for 7 days for measuring MVPA, and underwent the Brief International Cognitive Assessment in MS. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Cardiorespiratory fitness was not significantly correlated with Symbol Digit Modalities Test (SDMT; r = −0.01; r = −0.04), California Verbal Learning Test-II (CVLT-II; r = 0.05; r = 0.05), or Brief Visuospatial Memory Test–Revised (BVMT-R; r = −0.14; r = −0.14) z-scores controlling for age, sex, and education. MVPA and SDMT ( r = 0.05), CVLT-II ( r = −0.07), and BVMT-R ( r = 0.01) z-scores were not significantly correlated. </jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p> Cardiorespiratory fitness and MVPA were not associated with cognition in this large progressive MS sample, yet these outcomes represent critical manipulation checks for documenting the success of the CogEx trial. This highlights the importance of examining other exercise-related mechanisms-of-action for improving cognition in progressive MS. </jats:p></jats:sec>

dc.format.extent135245852110483 - 135245852110483en
dc.publisherSAGE Publicationsen
dc.titleCardiorespiratory fitness and free-living physical activity are not associated with cognition in persons with progressive multiple sclerosis: Baseline analyses from the CogEx studyen
dc.typeJournal Article
plymouth.journalMultiple Sclerosis Journalen
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Health Professions
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.rights.embargoperiodNot knownen
rioxxterms.typeJournal Article/Reviewen

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