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dc.contributor.authorZackowski, KMen
dc.contributor.authorFreeman, Jen
dc.contributor.authorBrichetto, Gen
dc.contributor.authorCentonze, Den
dc.contributor.authorDalgas, Uen
dc.contributor.authorDeLuca, Jen
dc.contributor.authorEhde, Den
dc.contributor.authorElgott, Sen
dc.contributor.authorFanning, Ven
dc.contributor.authorFeys, Pen
dc.contributor.authorFinlayson, Men
dc.contributor.authorGold, SMen
dc.contributor.authorInglese, Men
dc.contributor.authorMarrie, RAen
dc.contributor.authorPloughman, Men
dc.contributor.authorSang, CNen
dc.contributor.authorSastre-Garriga, Jen
dc.contributor.authorSincock, Cen
dc.contributor.authorStrum, Jen
dc.contributor.authorvan Beek, Jen
dc.contributor.authorFeinstein, Aen
dc.date.accessioned2021-04-27T07:54:27Z
dc.date.available2021-04-27T07:54:27Z
dc.date.issued2021-03-15en
dc.identifier.issn1352-4585en
dc.identifier.urihttp://hdl.handle.net/10026.1/17072
dc.description.abstract

<jats:sec><jats:title>Background:</jats:title><jats:p> People with multiple sclerosis (MS) experience myriad symptoms that negatively affect their quality of life. Despite significant progress in rehabilitation strategies for people living with relapsing-remitting MS (RRMS), the development of similar strategies for people with progressive MS has received little attention. </jats:p></jats:sec><jats:sec><jats:title>Objective:</jats:title><jats:p> To highlight key symptoms of importance to people with progressive MS and stimulate the design and implementation of high-quality studies focused on symptom management and rehabilitation. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> A group of international research experts, representatives from industry, and people affected by progressive MS was convened by the International Progressive MS Alliance to devise research priorities for addressing symptoms in progressive MS. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Based on information from the MS community, we outline a rationale for highlighting four symptoms of particular interest: fatigue, mobility and upper extremity impairment, pain, and cognitive impairment. Factors such as depression, resilience, comorbidities, and psychosocial support are described, as they affect treatment efficacy. </jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p> This coordinated call to action—to the research community to prioritize investigation of effective symptom management strategies, and to funders to support them—is an important step in addressing gaps in rehabilitation research for people affected by progressive MS. </jats:p></jats:sec>

en
dc.format.extent135245852199997 - 135245852199997en
dc.languageenen
dc.language.isoenen
dc.publisherSAGE Publicationsen
dc.titlePrioritizing progressive MS rehabilitation research: A call from the International Progressive MS Allianceen
dc.typeJournal Article
plymouth.journalMultiple Sclerosis Journalen
dc.identifier.doi10.1177/1352458521999970en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Health Professions
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dcterms.dateAccepted2021-02-07en
dc.rights.embargodate2021-04-28en
dc.identifier.eissn1477-0970en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1177/1352458521999970en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2021-03-15en
rioxxterms.typeJournal Article/Reviewen


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