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dc.contributor.authorKhanal, Sen
dc.contributor.authorThapa, Men
dc.contributor.authorRacette, Len
dc.contributor.authorJohnson, Ren
dc.contributor.authorDavey, PGen
dc.contributor.authorJoshi, MRen
dc.contributor.authorShrestha, GSen
dc.date.accessioned2020-09-15T08:43:39Z
dc.date.available2020-09-15T08:43:39Z
dc.date.issued2014-10en
dc.identifier.urihttp://hdl.handle.net/10026.1/16299
dc.description.abstract

BACKGROUND: To evaluate peripapillary retinal nerve fiber layer (RNFL) thickness in glaucomatous Nepalese eyes using spectral domain optical coherence tomography (SD-OCT) and study its relationship with visual field sensitivity. METHODS: A total of 120 eyes comprising primary open angle glaucoma (POAG), glaucoma suspects (GS), normal tension glaucoma (NTG) and healthy subjects (n=30 cases in each group) underwent a complete ophthalmic examination, including optic nerve head (ONH) evaluation and standard automated perimetry (SAP). RNFL thickness measurements around the optic disk were taken with circular spectral domain optical coherence tomography (SD-OCT) scans. Analysis of variance (ANOVA) was used for comparison of RNFL parameters among various study groups. The relationship of RNFL parameters with visual field (VF) global indices was evaluated with regression analysis. RESULTS: The mean pRNFL thickness was significantly less in the POAG (64.30±14.45μm, p<0.01), NTG (85.43±9.79μm, p<0.001) and GS (102.0±9.37μm, p<0.001) groups than in the healthy group (109.8±8.32μm). The RNFL was significantly thinner across all quadrants in all study group pairs (p<0.05) except for normal vs. GS (only superior and inferior quadrant, significant). Linear regression plots with RNFL thickness as a predictor of MD and LV demonstrated a strong and statistically significant degree of determination in the POAG group (R(2)=0.203 and 0.175, p=0.013 and 0.021). CONCLUSION: The RNFL thickness measurements with SD-OCT are lower in glaucomatous eyes as compared to age-matched GS and normal eyes in the Nepalese population. A high resolution SD-OCT could aid significantly in the early diagnosis of glaucoma in Nepal.

en
dc.format.extent217 - 224en
dc.languageengen
dc.language.isoengen
dc.subjectCampo visualen
dc.subjectCapa de fibras nerviosasen
dc.subjectGlaucomaen
dc.subjectGlaucoma primario de ángulo abiertoen
dc.subjectNerve fiber layeren
dc.subjectOptical coherence tomographyen
dc.subjectPrimary open angle glaucomaen
dc.subjectTomografía de coherencia ópticaen
dc.subjectVisual fielden
dc.subjectAdulten
dc.subjectAnalysis of Varianceen
dc.subjectAsian Continental Ancestry Groupen
dc.subjectCase-Control Studiesen
dc.subjectCross-Sectional Studiesen
dc.subjectEarly Diagnosisen
dc.subjectFemaleen
dc.subjectGlaucomaen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNepalen
dc.subjectNerve Fibersen
dc.subjectRetinal Ganglion Cellsen
dc.subjectTomography, Optical Coherenceen
dc.subjectVisual Fieldsen
dc.titleRetinal nerve fiber layer thickness in glaucomatous Nepalese eyes and its relation with visual field sensitivity.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/25323643en
plymouth.issue4en
plymouth.volume7en
plymouth.publication-statusPublisheden
plymouth.journalJ Optomen
dc.identifier.doi10.1016/j.optom.2014.05.002en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Health Professions
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeSpainen
dcterms.dateAccepted2014-04-09en
dc.identifier.eissn1989-1342en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1016/j.optom.2014.05.002en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-10en
rioxxterms.typeJournal Article/Reviewen


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