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dc.contributor.authorThomas, Ben
dc.contributor.authorSmallwood, Sen
dc.contributor.authorCutler, Cen
dc.contributor.authorBescos, Ren
dc.date.accessioned2019-03-28T23:04:41Z
dc.date.issued2019-06-01en
dc.identifier.issn1089-8603en
dc.identifier.urihttp://hdl.handle.net/10026.1/13578
dc.description.abstract

Interest in inorganic nitrate and nitrite has grown substantially over the past decade as research has revealed the role of these anions in enhancing nitric oxide (NO) availability through an oral pathway. Nitrite synthesis in the mouth seems to be an important mechanism to feed the circulatory system with this anion. This is interesting since greater plasma nitrite concentration has been associated with better fitness levels in humans, but this question has not been investigated in relation to salivary nitrite concentration. Additionally, no previous study has investigated the oral nitrate-reducing capacity in regards to peak oxygen uptake (VO2peak) or peak power output (Wpeak) in humans. Thus, the main goal of this study was to investigate whether salivary nitrite and nitrate concentration and the oral nitrate-reducing capacity were associated with VO2peak and Wpeak in healthy humans. Fifty individuals (22 females and 28 males; 38.8 ± 14.3 years/old; BMI = 22.8 ± 3.9) performed a graded exercise test on a cycle ergometer to assess their VO2peak and Wpeak. Unstimulated salivary samples were taken before and 20 min after exercise to measure nitrate/nitrite, pH and lactate. The oral nitrate-reducing capacity was also assessed in 25 subjects before and after exercise. Oral nitrate-reducing capacity was positively associated with Wpeak (rs = 0.64; P = 0.001) and the VO2peak (rs = 0.54; P = 0.005). Similar correlations were found when these variables were analysed after exercise. In addition, a significant decrease in salivary pH (pre: 7.28 ± 0.361; post-exercise: 7.16 ± 0.33; P = 0.003) accompanied by an increase of salivary lactate (pre: 0.17 ± 0.14 mmol/L; post-exercise: 0.48 ± 0.38; P < 0.001) was found after exercise. However, these changes did not have any impact on salivary nitrate/nitrite concentration and the oral nitrate-reducing capacity after exercise. In conclusion, this is the first evidence showing a link between the oral nitrate-reducing capacity and markers of aerobic fitness levels in healthy humans.

en
dc.format.extent43 - 51en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectExerciseen
dc.subjectNitrateen
dc.subjectNitriteen
dc.subjectOral bacteriaen
dc.titleThe oral nitrate-reducing capacity correlates with peak power output and peak oxygen uptake in healthy humans.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/30853629en
plymouth.volume87en
plymouth.journalNitric Oxide: Biology and Chemistryen
dc.identifier.doi10.1016/j.niox.2019.03.001en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Health: Medicine, Dentistry and Human Sciences
plymouth.organisational-group/Plymouth/Faculty of Health: Medicine, Dentistry and Human Sciences/School of Health Professions
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
dcterms.dateAccepted2019-03-04en
dc.rights.embargodate2020-03-06en
dc.identifier.eissn1089-8611en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1016/j.niox.2019.03.001en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-06-01en
rioxxterms.typeJournal Article/Reviewen


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