Macrophage-Derived Slit3 Controls Cell Migration and Axon Pathfinding in the Peripheral Nerve Bridge
dc.contributor.author | Dun, X | |
dc.contributor.author | Carr, L | |
dc.contributor.author | Woodley, P | |
dc.contributor.author | Barry, R | |
dc.contributor.author | Drake, L | |
dc.contributor.author | Mindos, T | |
dc.contributor.author | Robert, S | |
dc.contributor.author | Lloyd, A | |
dc.contributor.author | Parkinson, D | |
dc.date.accessioned | 2019-02-11T10:07:48Z | |
dc.date.issued | 2019-02-05 | |
dc.identifier.issn | 2211-1247 | |
dc.identifier.issn | 2211-1247 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/13289 | |
dc.description | Article retracted. This is a metadata only record. | |
dc.description.abstract |
Slit-Robo signaling has been characterized as a repulsive signal for precise axon pathfinding and cell migration during embryonic development. Here, we describe a role for Sox2 in the regulation of Robo1 in Schwann cells and for Slit3-Robo1 signaling in controlling axon guidance within the newly formed nerve bridge following peripheral nerve transection injury. In particular, we show that macrophages form the outermost layer of the nerve bridge and secrete high levels of Slit3, while migratory Schwann cells and fibroblasts inside the nerve bridge express the Robo1 receptor. In line with this pattern of Slit3 and Robo1 expression, we observed multiple axon regeneration and cell migration defects in the nerve bridge of Sox2-, Slit3-, and Robo1-mutant mice. Our findings have revealed important functions for macrophages in the peripheral nervous system, utilizing Slit3-Robo1 signaling to control correct peripheral nerve bridge formation and precise axon targeting to the distal nerve stump following injury. | |
dc.format.extent | 1458-1472.e4 | |
dc.format.medium | ||
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Elsevier (Cell Press) | |
dc.subject | Robo1 | |
dc.subject | Schwann cell | |
dc.subject | Slit3 | |
dc.subject | Sox2 | |
dc.subject | fibroblast | |
dc.subject | injury | |
dc.subject | macrophages | |
dc.subject | migration | |
dc.subject | peripheral nerve | |
dc.subject | regeneration | |
dc.subject | Animals | |
dc.subject | Axon Guidance | |
dc.subject | Cell Movement | |
dc.subject | Cells, Cultured | |
dc.subject | Female | |
dc.subject | Fibroblasts | |
dc.subject | Macrophages | |
dc.subject | Male | |
dc.subject | Membrane Proteins | |
dc.subject | Mice | |
dc.subject | Mice, Inbred C57BL | |
dc.subject | Mutation | |
dc.subject | Nerve Regeneration | |
dc.subject | Nerve Tissue Proteins | |
dc.subject | Peripheral Nerves | |
dc.subject | Rats | |
dc.subject | Rats, Wistar | |
dc.subject | Receptors, Immunologic | |
dc.subject | SOXB1 Transcription Factors | |
dc.subject | Schwann Cells | |
dc.subject | Signal Transduction | |
dc.subject | Roundabout Proteins | |
dc.title | Macrophage-Derived Slit3 Controls Cell Migration and Axon Pathfinding in the Peripheral Nerve Bridge | |
dc.type | journal-article | |
dc.type | Article | |
dc.type | Retracted Publication | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/30726731 | |
plymouth.issue | 6 | |
plymouth.volume | 26 | |
plymouth.publication-status | Published | |
plymouth.journal | Cell Reports | |
dc.identifier.doi | 10.1016/j.celrep.2018.12.081 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2018-12-18 | |
dc.rights.embargodate | 2019-2-12 | |
dc.identifier.eissn | 2211-1247 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.funder | Wellcome Trust | |
rioxxterms.identifier.project | The role of Sox-2 in Schwann cell development and plasticity. | |
rioxxterms.versionofrecord | 10.1016/j.celrep.2018.12.081 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2019-02-05 | |
rioxxterms.type | Journal Article/Review | |
plymouth.funder | The role of Sox-2 in Schwann cell development and plasticity.::Wellcome Trust |