Show simple item record

dc.contributor.authorAggett, J.
dc.date.accessioned2018-11-08T13:46:34Z
dc.date.accessioned2018-11-19T12:21:56Z
dc.date.available2018-11-08T13:46:34Z
dc.date.available2018-11-19T12:21:56Z
dc.date.issued2008
dc.identifier.citation

Aggett, J. (2008) 'The Effect of Nucleotide-binding Oligomerization Domain (NOD)', The plymouth Student Scientist, 1(1), p.312-330

en_US
dc.identifier.issn1754-2383
dc.identifier.urihttp://hdl.handle.net/10026.1/12811
dc.description.abstract

The study of Nucleotide-Binding Oligomerization Domain (NOD) Proteins is a very new area of immunology, with the gene for NOD2 having only been mapped in 2001 (Ogura et al 2001). It holds particular significance for those researching autoimmune disorders such as Blau syndrome and Crohns Disease (CD), as it has been found that a mutation in the NOD2 gene is present in a substantial proportion of CD sufferers, and having the mutation increases a person‟s susceptibility to developing the disease later in life (Economou et al 2004). This review will look at the current research surrounding the NOD proteins and what products they form, and how this can be used to further our knowledge of CD and how it can be managed. It will be specifically looking into the effects that NOD proteins in macrophages have on the secretion of various pro- and anti-inflammatory cytokines and how these can be augmented by the interaction of NOD protein signalling pathways with those of other molecules in the cell.

en_US
dc.language.isoenen_US
dc.publisherUniversity of Plymouth
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.titleThe Effect of Nucleotide-binding Oligomerization Domain (NOD) Proteins on the Secretion of Cytokines from Macrophagesen_US
dc.typeArticle
plymouth.journalThe Plymouth Student Scientist


Files in this item

Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States

All items in PEARL are protected by copyright law.
Author manuscripts deposited to comply with open access mandates are made available in accordance with publisher policies. Please cite only the published version using the details provided on the item record or document. In the absence of an open licence (e.g. Creative Commons), permissions for further reuse of content should be sought from the publisher or author.
Theme by 
@mire NV