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dc.contributor.authorMartinez-Martin, Pen
dc.contributor.authorRizos, AMen
dc.contributor.authorWetmore, Jen
dc.contributor.authorAntonini, Aen
dc.contributor.authorOdin, Pen
dc.contributor.authorPal, Sen
dc.contributor.authorSophia, Ren
dc.contributor.authorCarroll, Cen
dc.contributor.authorMartino, Den
dc.contributor.authorFalup-Pecurariu, Cen
dc.contributor.authorKessel, Ben
dc.contributor.authorAndrews, Ten
dc.contributor.authorPaviour, Den
dc.contributor.authorTrenkwalder, Cen
dc.contributor.authorChaudhuri, KRen
dc.contributor.authorEUROPAR & MDS Non-Motor PD Study Groupen

BACKGROUND: Pain is highly prevalent in Parkinson's disease (PD), impacting patients' ability, mood, and quality of life. Detecting the presence of pain in its multiple modalities is necessary for adequate personalized management of PD. A 14-item, PD-specific, patient-based questionnaire (the King's Parkinson's disease Pain Questionnaire, KPPQ) was designed corresponding to the rater-based KPP Scale (KPPS). The present multi-center study was aimed at testing the validity of this screening tool. METHODS: First, a comparison between the KPPQ scores of patients and matched controls was performed. Next, convergent validity, reproducibility (test-retest), and diagnostic performance of the questionnaire were analyzed. RESULTS: We report data from 300 patients and 150 controls. PD patients declared significantly more pain symptoms than controls (3.96±2.56 vs. 2.17±1.39; p<0.0001). KPPQ convergent validity with KPPS total score was high (rS = 0.80), but weak or moderate with other pain assessments. Test-retest reliability was satisfactory with kappa values ≥0.65, except for item 5, Dyskinetic pains (kappa=0.44) and ICC for the KPPQ total score 0.98. After the scores of the KPPS were adapted for screening (0= no symptom; ≥1= symptom present), a high agreement was found between the KPPQ and the KPPS (ICC =0.88). A strong correlation (rS = 0.80) between both instruments was found. The diagnostic parameters of the KPPQ were very satisfactory as a whole, with a global accuracy of 78.3%-98.3%. CONCLUSIONS: These results suggest that the KPPQ is a useful, reliable, and valid screening instrument of pain in PD to advance patient-related outcomes. This article is protected by copyright. All rights reserved.

dc.format.extent1255 - 1261en
dc.subjectKing's Parkinson's disease Pain Questionnaireen
dc.subjectParkinson's diseaseen
dc.titleFirst comprehensive tool for screening pain in Parkinson's disease: The King's Parkinson's Disease Pain Questionnaire (KPPQ).en
dc.typeJournal Article
plymouth.journalEuropean Journal of Neurologyen
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Centre for Clinical Trials & Health Research
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Centre for Clinical Trials & Health Research/RC reporting group CTPS
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Collaboration for the Advancement of Medical Education Research Assessment
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Neuroscience
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CCT&PS
dc.rights.embargoperiod12 monthsen
rioxxterms.typeJournal Article/Reviewen

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