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dc.contributor.authorBrockmeier, EKen
dc.contributor.authorHodges, Gen
dc.contributor.authorHutchinson, THen
dc.contributor.authorButler, Een
dc.contributor.authorHecker, Men
dc.contributor.authorTollefsen, KEen
dc.contributor.authorGarcia-Reyero, Nen
dc.contributor.authorKille, Pen
dc.contributor.authorBecker, Den
dc.contributor.authorChipman, Ken
dc.contributor.authorColbourne, Jen
dc.contributor.authorCollette, TWen
dc.contributor.authorCossins, Aen
dc.contributor.authorCronin, Men
dc.contributor.authorGraystock, Pen
dc.contributor.authorGutsell, Sen
dc.contributor.authorKnapen, Den
dc.contributor.authorKatsiadaki, Ien
dc.contributor.authorLange, Aen
dc.contributor.authorMarshall, Sen
dc.contributor.authorOwen, SFen
dc.contributor.authorPerkins, EJen
dc.contributor.authorPlaistow, Sen
dc.contributor.authorSchroeder, Aen
dc.contributor.authorTaylor, Den
dc.contributor.authorViant, Men
dc.contributor.authorAnkley, Gen
dc.contributor.authorFalciani, Fen
dc.date.accessioned2018-05-10T08:34:49Z
dc.date.available2018-05-10T08:34:49Z
dc.date.issued2017-08-01en
dc.identifier.urihttp://hdl.handle.net/10026.1/11478
dc.description.abstract

In conjunction with the second International Environmental Omics Symposium (iEOS) conference, held at the University of Liverpool (United Kingdom) in September 2014, a workshop was held to bring together experts in toxicology and regulatory science from academia, government and industry. The purpose of the workshop was to review the specific roles that high-content omics datasets (eg, transcriptomics, metabolomics, lipidomics, and proteomics) can hold within the adverse outcome pathway (AOP) framework for supporting ecological and human health risk assessments. In light of the growing number of examples of the application of omics data in the context of ecological risk assessment, we considered how omics datasets might continue to support the AOP framework. In particular, the role of omics in identifying potential AOP molecular initiating events and providing supportive evidence of key events at different levels of biological organization and across taxonomic groups was discussed. Areas with potential for short and medium-term breakthroughs were also discussed, such as providing mechanistic evidence to support chemical read-across, providing weight of evidence information for mode of action assignment, understanding biological networks, and developing robust extrapolations of species-sensitivity. Key challenges that need to be addressed were considered, including the need for a cohesive approach towards experimental design, the lack of a mutually agreed framework to quantitatively link genes and pathways to key events, and the need for better interpretation of chemically induced changes at the molecular level. This article was developed to provide an overview of ecological risk assessment process and a perspective on how high content molecular-level datasets can support the future of assessment procedures through the AOP framework.

en
dc.format.extent252 - 262en
dc.languageengen
dc.language.isoengen
dc.subjectin vitro and alternativesen
dc.subjectmethodsen
dc.subjectpredictive toxicologyen
dc.subjectregulatory/policyen
dc.subjectrisk assessmenten
dc.subjecttoxicogenomicsen
dc.subjectAdverse Outcome Pathwaysen
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectLipid Metabolismen
dc.subjectMetabolomicsen
dc.subjectProteomicsen
dc.subjectRisk Assessmenten
dc.subjectTranscriptomeen
dc.titleThe Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/28525648en
plymouth.issue2en
plymouth.volume158en
plymouth.publication-statusPublisheden
plymouth.journalToxicol Scien
dc.identifier.doi10.1093/toxsci/kfx097en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Geography, Earth and Environmental Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA06 Agriculture, Veterinary and Food Science
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/BEACh
dc.publisher.placeUnited Statesen
dc.identifier.eissn1096-0929en
dc.rights.embargoperiodNo embargoen
rioxxterms.versionofrecord10.1093/toxsci/kfx097en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.typeJournal Article/Reviewen


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