Probiotic treatment reduces appetite and glucose level in the zebrafish model
dc.contributor.author | Falcinelli, S | |
dc.contributor.author | Rodiles, A | |
dc.contributor.author | Unniappan, S | |
dc.contributor.author | Picchietti, S | |
dc.contributor.author | Gioacchini, G | |
dc.contributor.author | Merrifield, DL | |
dc.contributor.author | Carnevali, O | |
dc.date.accessioned | 2018-02-20T21:04:28Z | |
dc.date.available | 2018-02-20T21:04:28Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.other | 18061 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/10832 | |
dc.description.abstract |
<jats:title>Abstract</jats:title><jats:p>The gut microbiota regulates metabolic pathways that modulate the physiological state of hunger or satiety. Nutrients in the gut stimulate the release of several appetite modulators acting at central and peripheral levels to mediate appetite and glucose metabolism. After an eight-day exposure of zebrafish larvae to probiotic <jats:italic>Lactobacillus rhamnosus</jats:italic>, high-throughput sequence analysis evidenced the ability of the probiotic to modulate the microbial composition of the gastrointestinal tract. These changes were associated with a down-regulation and up-regulation of larval orexigenic and anorexigenic genes, respectively, an up-regulation of genes related to glucose level reduction and concomitantly reduced appetite and body glucose level. BODIPY-FL-pentanoic-acid staining revealed higher short chain fatty acids levels in the intestine of treated larvae. These results underline the capability of the probiotic to modulate the gut microbiota community and provides insight into how the probiotic interacts to regulate a novel gene network involved in glucose metabolism and appetite control, suggesting a possible role for <jats:italic>L. rhamnosus</jats:italic> in the treatment of impaired glucose tolerance and food intake disorders by gut microbiota manipulation.</jats:p> | |
dc.format.extent | 18061- | |
dc.format.medium | Electronic | |
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.subject | Animals | |
dc.subject | Appetite | |
dc.subject | Fatty Acids | |
dc.subject | Gastrointestinal Absorption | |
dc.subject | Gastrointestinal Microbiome | |
dc.subject | Gastrointestinal Tract | |
dc.subject | Gene Expression | |
dc.subject | Glucose | |
dc.subject | Larva | |
dc.subject | Probiotics | |
dc.subject | Zebrafish | |
dc.title | Probiotic treatment reduces appetite and glucose level in the zebrafish model | |
dc.type | journal-article | |
dc.type | Article | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/26727958 | |
plymouth.issue | 1 | |
plymouth.volume | 6 | |
plymouth.publication-status | Published online | |
plymouth.journal | Scientific Reports | |
dc.identifier.doi | 10.1038/srep18061 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Science and Engineering | |
plymouth.organisational-group | /Plymouth/Faculty of Science and Engineering/School of Biological and Marine Sciences | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA06 Agriculture, Veterinary and Food Science | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | England | |
dcterms.dateAccepted | 2015-11-03 | |
dc.identifier.eissn | 2045-2322 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1038/srep18061 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2016-01-05 | |
rioxxterms.type | Journal Article/Review |