Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection
dc.contributor.author | Huang, H | |
dc.contributor.author | Duggal, P | |
dc.contributor.author | Thio, CL | |
dc.contributor.author | Latanich, R | |
dc.contributor.author | Goedert, JJ | |
dc.contributor.author | Mangia, A | |
dc.contributor.author | Cox, AL | |
dc.contributor.author | Kirk, GD | |
dc.contributor.author | Mehta, S | |
dc.contributor.author | Aneja, J | |
dc.contributor.author | Alric, L | |
dc.contributor.author | Donfield, SM | |
dc.contributor.author | Cramp, Matthew | |
dc.contributor.author | Khakoo, SI | |
dc.contributor.author | Tobler, LH | |
dc.contributor.author | Busch, M | |
dc.contributor.author | Alexander, GJ | |
dc.contributor.author | Rosen, HR | |
dc.contributor.author | Edlin, BR | |
dc.contributor.author | Segal, FP | |
dc.contributor.author | Lauer, GM | |
dc.contributor.author | Thomas, DL | |
dc.contributor.author | Daly, MJ | |
dc.contributor.author | Chung, RT | |
dc.contributor.author | Kim, AY | |
dc.date.accessioned | 2018-01-29T15:19:22Z | |
dc.date.available | 2018-01-29T15:19:22Z | |
dc.date.issued | 2017-11-20 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.other | ARTN 15843 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/10682 | |
dc.description.abstract |
<jats:title>Abstract</jats:title><jats:p>Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the <jats:italic>IL28B/IFNL4</jats:italic> and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population. We further fine-mapped the association in the MHC to a region of about 50 kilo base pairs, down from 1 mega base pairs in the previous study. Additional analyses suggested that the association in MHC is stronger in samples from North America than those from Europe.</jats:p> | |
dc.format.extent | 15843- | |
dc.format.medium | Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Nature Publishing Group | |
dc.subject | Europe | |
dc.subject | Female | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Genotype | |
dc.subject | Hepacivirus | |
dc.subject | Hepatitis C | |
dc.subject | Humans | |
dc.subject | Interferons | |
dc.subject | Interleukins | |
dc.subject | Major Histocompatibility Complex | |
dc.subject | Male | |
dc.subject | North America | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.title | Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection | |
dc.type | journal-article | |
dc.type | Journal Article | |
plymouth.author-url | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000415692800015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 1 | |
plymouth.volume | 7 | |
plymouth.publication-status | Published | |
plymouth.journal | Scientific Reports | |
dc.identifier.doi | 10.1038/s41598-017-16011-2 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | England | |
dcterms.dateAccepted | 2017-11-06 | |
dc.identifier.eissn | 2045-2322 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1038/s41598-017-16011-2 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2017-11-20 | |
rioxxterms.type | Journal Article/Review |