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dc.contributor.authorHuang, H
dc.contributor.authorDuggal, P
dc.contributor.authorThio, CL
dc.contributor.authorLatanich, R
dc.contributor.authorGoedert, JJ
dc.contributor.authorMangia, A
dc.contributor.authorCox, AL
dc.contributor.authorKirk, GD
dc.contributor.authorMehta, S
dc.contributor.authorAneja, J
dc.contributor.authorAlric, L
dc.contributor.authorDonfield, SM
dc.contributor.authorCramp, ME
dc.contributor.authorKhakoo, SI
dc.contributor.authorTobler, LH
dc.contributor.authorBusch, M
dc.contributor.authorAlexander, GJ
dc.contributor.authorRosen, HR
dc.contributor.authorEdlin, BR
dc.contributor.authorSegal, FP
dc.contributor.authorLauer, GM
dc.contributor.authorThomas, DL
dc.contributor.authorDaly, MJ
dc.contributor.authorChung, RT
dc.contributor.authorKim, AY
dc.date.accessioned2018-01-29T15:19:22Z
dc.date.available2018-01-29T15:19:22Z
dc.date.issued2017-11-20
dc.identifier.issn2045-2322
dc.identifier.issn2045-2322
dc.identifier.otherARTN 15843
dc.identifier.urihttp://hdl.handle.net/10026.1/10682
dc.description.abstract

<jats:title>Abstract</jats:title><jats:p>Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the <jats:italic>IL28B/IFNL4</jats:italic> and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population. We further fine-mapped the association in the MHC to a region of about 50 kilo base pairs, down from 1 mega base pairs in the previous study. Additional analyses suggested that the association in MHC is stronger in samples from North America than those from Europe.</jats:p>

dc.format.extent15843-
dc.format.mediumElectronic
dc.languageen
dc.language.isoen
dc.publisherNature Publishing Group
dc.subjectEurope
dc.subjectFemale
dc.subjectGenetic Predisposition to Disease
dc.subjectGenome-Wide Association Study
dc.subjectGenotype
dc.subjectHepacivirus
dc.subjectHepatitis C
dc.subjectHumans
dc.subjectInterferons
dc.subjectInterleukins
dc.subjectMajor Histocompatibility Complex
dc.subjectMale
dc.subjectNorth America
dc.subjectPolymorphism, Single Nucleotide
dc.titleFine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000415692800015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue1
plymouth.volume7
plymouth.publisher-urlhttp://dx.doi.org/10.1038/s41598-017-16011-2
plymouth.publication-statusPublished
plymouth.journalScientific Reports
dc.identifier.doi10.1038/s41598-017-16011-2
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeEngland
dcterms.dateAccepted2017-11-06
dc.identifier.eissn2045-2322
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1038/s41598-017-16011-2
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-11-20
rioxxterms.typeJournal Article/Review


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