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dc.contributor.authorHickson, M
dc.date.accessioned2018-01-22T11:47:42Z
dc.date.available2018-01-22T11:47:42Z
dc.date.issued2015-11
dc.identifier.issn0029-6651
dc.identifier.issn1475-2719
dc.identifier.urihttp://hdl.handle.net/10026.1/10644
dc.description.abstract

<jats:p>The aim of the present paper is to critically review the details of the published nutrition intervention trials, with and without exercise, targeting sarcopenia. Sarcopenia is the loss of muscle mass, strength and/or performance with age. Since amino acids and energy are required for muscle synthesis it is possible that nutritional intake influences sarcopenia. Nutritional studies are challenging to carry out because of the complexity of modulating dietary intake. It is very difficult to change one nutrient without influencing many others, which means that many of the published studies are problematic to interpret. The studies included evaluate whole protein, essential amino acids and β-hydroxyl β-methylbutyrate (HMB). Whole-protein supplementation failed to show a consistent effect on muscle mass, strength or function. This can be explained by the variations in study design, composition of the protein supplement and the failure to monitor voluntary food intake, adherence and baseline nutritional status. Essential amino-acid supplements showed an inconsistent effect but there are only two trials that have significant differences in methodology and the supplement used. The HMB studies are suggestive of a beneficial effect on older adults, but larger well-controlled studies are required that measure outcomes relevant to sarcopenia, ideally in sarcopenic populations. The issues of timing and distribution of protein intake, and increased splanchnic amino-acid sequestration are discussed, and recommendations for future trials are made.</jats:p>

dc.format.extent378-386
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoeng
dc.publisherCambridge University Press (CUP)
dc.subjectSarcopenia
dc.subjectVitamin D
dc.subjectProtein
dc.subjectEssential amino acid
dc.subjectbeta-Hydroxyl beta-methylbutyrate
dc.titleNutritional interventions in sarcopenia: a critical review
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/25923603
plymouth.issue4
plymouth.volume74
plymouth.publisher-urlhttp://dx.doi.org/10.1017/s0029665115002049
plymouth.publication-statusPublished
plymouth.journalProceedings of the Nutrition Society
dc.identifier.doi10.1017/s0029665115002049
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Health Professions
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR)
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeEngland
dc.identifier.eissn1475-2719
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1017/s0029665115002049
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review


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