Notch signaling from tumor cells: a new mechanism of angiogenesis.
dc.contributor.author | Li, J-L | en |
dc.contributor.author | Harris, AL | en |
dc.date.accessioned | 2017-11-29T13:11:29Z | |
dc.date.available | 2017-11-29T13:11:29Z | |
dc.date.issued | 2005-07 | en |
dc.identifier.issn | 1535-6108 | en |
dc.identifier.uri | http://hdl.handle.net/10026.1/10344 | |
dc.description.abstract |
Notch signaling is an evolutionarily conserved pathway and plays key roles in embryonic vascular development and angiogenesis. Multiple components of the Notch pathway are expressed in vasculature, and mice deficient for a variety of these components display embryonic lethality with vascular remodeling defects. Alteration of Notch signaling in various endothelial cells generates profound effects on angiogenesis in vitro. New evidence shows that Notch signaling from tumor cells is able to activate endothelial cells and trigger tumor angiogenesis in vitro and in a xenograft mouse tumor model. Selective interruption of Notch signaling within tumors may provide an antiangiogenic strategy. | en |
dc.format.extent | 1 - 3 | en |
dc.language | eng | en |
dc.language.iso | eng | en |
dc.subject | Angiogenesis Inhibitors | en |
dc.subject | Animals | en |
dc.subject | Humans | en |
dc.subject | Membrane Proteins | en |
dc.subject | Neoplasms | en |
dc.subject | Neovascularization, Pathologic | en |
dc.subject | Receptors, Cell Surface | en |
dc.subject | Receptors, Notch | en |
dc.subject | Signal Transduction | en |
dc.title | Notch signaling from tumor cells: a new mechanism of angiogenesis. | en |
dc.type | Journal Article | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/16023591 | en |
plymouth.issue | 1 | en |
plymouth.volume | 8 | en |
plymouth.publication-status | Published | en |
plymouth.journal | Cancer Cell | en |
dc.identifier.doi | 10.1016/j.ccr.2005.06.013 | en |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine | |
dc.publisher.place | United States | en |
dc.rights.embargoperiod | Not known | en |
rioxxterms.versionofrecord | 10.1016/j.ccr.2005.06.013 | en |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | en |
rioxxterms.type | Journal Article/Review | en |