Role of the Bloom's syndrome helicase in maintenance of genome stability.
Date
2001-05Author
Hickson, ID
Davies, SL
Li, JL
Levitt, NC
Mohaghegh, P
North, PS
Wu, L
Subject
Adenosine Triphosphatases Bloom Syndrome Chromosome Aberrations DNA Helicases Genome, Human Humans Phenotype Protein Binding Protein Structure, Tertiary Protein Transport RecQ Helicases Recombination, Genetic
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Show full item recordAbstract
The RecQ family of DNA helicases has members in all organisms analysed. In humans, defects in three family members are associated with disease conditions: BLM is defective in Bloom's syndrome, WRN in Werner's syndrome and RTS in Rothmund-Thomson syndrome. In each case, cells from affected individuals show inherent genomic instability. The focus of our work is the Bloom's syndrome gene and its product, BLM. Here, we review the latest information concerning the roles of BLM in the maintenance of genome integrity.
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Place of Publication
England
Journal
Biochem Soc Trans
Volume
29
Issue
Pt 2
Pagination
201 - 204
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