ORCID
- Steven J Rowland: 0000-0003-4980-0618
- Michael J Wilde: 0000-0003-0726-890X
Abstract
The use of atmospheric pressure chemical ionisation (APCI) compact mass spectrometry (CMS) was investigated for the analysis of jetsam and museum-archived ambergris and of ambergris components in perfumes. The data were compared with those from existing methods. Authentic samples of some individual ambergris constituents (ambrein, coprostanol, epicoprostanol and coprostanone), were also examined. Rapid APCI CMS was achieved using either a solids probe or a probe with solutions held in capillary melting point tubes. Interpretation is made of the spectra of the principal natural product components, the relative ion responses were measured and the elemental composition of key ions in the spectra confirmed using high resolution accurate mass APCI MS. Rapid analysis of ambergris by APCI CMS may prove to be a further convenient method of identifying ambrein, of measuring the relative ratios of ambrein and steroids in ambergris and even of quantifying the latter, with minimal sample preparation.
DOI
10.1080/14786419.2024.2321496
Publication Date
2024-02-28
Publication Title
Natural Product Research
ISSN
1478-6419
Keywords
APCI, Ambergris, CMS, ambrein, coprostanol, coprostanone, epicoprostanol, jetsam, sperm whale
First Page
1
Last Page
7
Recommended Citation
Rowland, S., Wilde, M., Sutton, P., Blackbird, S., & Wolff, G. (2024) 'If speed is of the essence: rapid analysis of ambergris by APCI compact mass spectrometry', Natural Product Research, , pp. 1-7. Available at: https://doi.org/10.1080/14786419.2024.2321496
