Abstract
The advent of adverse outcome pathways (AOPs) has provided a new lexicon for description of mechanistic toxicology, and a renewed enthusiasm for exploring modes of action resulting in adverse health and environmental effects. In addition, AOPs have been used successfully as a framework for the design and development of non-animal approaches to toxicity testing. Although the value of AOPs is widely recognised, there remain challenges and opportunities associated with their use in practise. The purpose of this article is to consider specifically how the future trajectory of AOPs may provide a basis for addressing some of those challenges and opportunities.
DOI
10.1007/s00204-018-2183-2
Publication Date
2018-04-01
Publication Title
Archives of Toxicology
Volume
92
Issue
4
ISSN
0340-5761
Embargo Period
2018-06-15
Organisational Unit
School of Geography, Earth and Environmental Sciences
Keywords
Adverse outcome pathways (AOPs), Hazard identification, Risk assessment, Safety assessment
First Page
1657
Last Page
1661
Recommended Citation
Sewell, F., Gellatly, N., Beaumont, M., Burden, N., Currie, R., de, H., Hutchinson, T., Jacobs, M., Mahony, C., Malcomber, I., Mehta, J., Whale, G., & Kimber, I. (2018) 'The future trajectory of adverse outcome pathways: a commentary', Archives of Toxicology, 92(4), pp. 1657-1661. Available at: https://doi.org/10.1007/s00204-018-2183-2
