Abstract

The cytotoxic drug, cisplatin (cis-PtCl(2)(NH(3))(2)), has been added to cultures of the marine macroalga, Ulva lactuca, under various experimental conditions. Both accumulation and internalisation over a 48 h period was greater when cisplatin was added to coastal sea water (salinity = 33) from a distilled water solution than when added to either sea water or estuarine water (salinity = 16.5) from a saline solution. This effect is attributed to the greater abundance of the more reactive monoaqua complex (cis-PtCl(OH(2))(NH(3))(2)(+)) in the distilled water solution and kinetic constraints on its conversion back to cis-PtCl(2)(NH(3))(2) in sea water. Despite its mode of action at the cellular level, cisplatin added up to concentrations of 150 nM did not incur a measurable reduction in the efficiency of photochemical energy conversion under any of experimental conditions tested.

DOI

10.1016/j.envpol.2011.08.018

Publication Date

2011-12-01

Publication Title

Environ Pollut

Volume

159

Issue

12

Organisational Unit

School of Geography, Earth and Environmental Sciences

Keywords

Antineoplastic Agents, Cisplatin, Environmental Monitoring, Seawater, Seaweed, Ulva, Water Pollutants, Chemical

First Page

3504

Last Page

3508

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